Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates (NeoCLEAR): an open-label, 2 × 2 factorial, randomised, controlled trial

Marshall, Andrew S. J.; Scrivens, Alexandra; Bell, Jennifer L.; Linsell, Louise; Hardy, Pollyanna; Yong, Jean; Williams, Rachel; Adams, Eleri; Sadarangani, Manish; Juszczak, Edmund; Roehr, Charles C.; NeoCLEAR Collaborative Group

Abstract

Background Newborn infants are the highest-risk age group for bacterial meningitis. Lumbar punctures are therefore frequently performed in neonates, but success rates are low (50-60%). In Neonatal Champagne Lumbar punctures Every time-A Randomised Controlled Trial (NeoCLEAR), we sought to optimise infant lumbar puncture by evaluating two modifications to traditional technique: sitting position versus lying down and early stylet removal (stylet removal after transecting the subcutaneous tissue) versus late stylet removal.

Citation

Marshall, A. S. J., Scrivens, A., Bell, J. L., Linsell, L., Hardy, P., Yong, J., … NeoCLEAR Collaborative Group. (2023). Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates (NeoCLEAR): an open-label, 2 × 2 factorial, randomised, controlled trial. The Lancet Child & Adolescent Health, 7(2), 91-100. https://doi.org/10.1016/s2352-4642%2822%2900343-1

• Journal Article Type: Article
• Acceptance Date: Nov 28, 2022
• Online Publication Date: Nov 29, 2022
• Publication Date: Feb 1, 2023
• Deposit Date: Nov 30, 2022
• Publicly Available Date: Nov 30, 2022
• Journal: The Lancet Child and Adolescent Health
• Print ISSN: 2352-4642
• Electronic ISSN: 2352-4642
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 2
• Pages: 91-100
• DOI: https://doi.org/10.1016/s2352-4642%2822%2900343-1
• Keywords: Developmental and Educational Psychology; Pediatrics, Perinatology and Child Health
• Public URL: https://nottingham-repository.worktribe.com/output/14314193
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S2352464222003431
• Additional Information: Article Title: Assessment of infant position and timing of stylet removal to improve lumbar puncture success in neonates (NeoCLEAR): an open-label, 2 × 2 factorial, randomised, controlled trial; Journal Title: The Lancet Child & Adolescent Health; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/S2352-4642(22)00343-1; CrossRef DOI link to the associated document: https://doi.org/10.1016/S2352-4642(22)00345-5;