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Intestinal organoids for modelling intestinal development and disease

Fair, Kathryn L.; Colquhoun, Jennifer; Hannan, Nicholas R. F.

Authors

Kathryn L. Fair

Jennifer Colquhoun

NICK HANNAN NICK.HANNAN@NOTTINGHAM.AC.UK
Associate Professor



Abstract

Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific models of intestinal development and disease are desperately needed that can recapitulate structure and function of the gut in vitro. Advances in pluripotent stem cells and primary tissue culture techniques have made it possible to culture intestinal epithelial cells in three dimensions that self-assemble to form ‘intestinal organoids'. These organoids allow for new, human-specific models that can be used to gain insight into gastrointestinal disease and potentially deliver new therapies to treat them. Here we review current in vitro models of intestinal development and disease, considering where improvements could be made and potential future applications in the fields of developmental modelling, drug/toxicity testing and therapeutic uses.

Journal Article Type Article
Acceptance Date Feb 21, 2018
Online Publication Date May 21, 2018
Publication Date Jul 5, 2018
Deposit Date Dec 5, 2018
Journal Philosophical Transactions of the Royal Society B: Biological Sciences
Print ISSN 0962-8436
Electronic ISSN 1471-2970
Publisher The Royal Society
Peer Reviewed Peer Reviewed
Volume 373
Issue 1750
Article Number 20170217
DOI https://doi.org/10.1098/rstb.2017.0217
Public URL https://nottingham-repository.worktribe.com/output/1370404
Publisher URL https://royalsocietypublishing.org/doi/10.1098/rstb.2017.0217