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Morphogenesis of the papillary lesions of the breast: phenotypic observation

Rakha, Emad A.


Professor of Breast Cancer Pathology


Papillary lesions of the breast are a heterogeneous group of diseases characterised by the presence epithelial proliferation supported by fibrovascular stalks. Normal breast tissue does not show papillary morphology and the mechanisms underlying papillary morphogenesis in breast tumours remain poorly understood. Current clinical evidence indicates an indolent behaviour of malignant papillary breast tumours. Herein, we present some phenotypic features that may explain the development of papillary morphology of breast lesions. Active papillary morphogenesis, which appears to reflect a unique mechanism involving interaction between epithelial and mesenchymal elements, is best appreciated in intraductal papilloma and papillary carcinoma. Morphological evidence suggests papillary morphogenesis during oncogenesis is a dynamic process with variable degrees of papillary differentiation among the same lesion and between primary and metastatic tumours. Secondary papillary-like architecture of non-papillary breast lesions exists. Further studies of the molecular mechanisms underlying papillary morphogenesis in the breast and its association with a better outcome are warranted.


Rakha, E. A. (2016). Morphogenesis of the papillary lesions of the breast: phenotypic observation. Journal of Clinical Pathology, 69(1), 64-69. doi:10.1136/jclinpath-2015-203191

Journal Article Type Article
Acceptance Date Jul 5, 2015
Online Publication Date Aug 6, 2015
Publication Date 2016-01
Deposit Date Nov 20, 2018
Journal Journal of Clinical Pathology
Print ISSN 0021-9746
Electronic ISSN 1472-4146
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 69
Issue 1
Pages 64-69
Public URL
Publisher URL