Constance E. Clare
One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development
Clare, Constance E.; Brassington, Amey H.; Kwong, Wing Yee; Sinclair, Kevin D.
Amey H. Brassington
Wing Yee Kwong
KEVIN SINCLAIR email@example.com
Professor of Developmental Biology
One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that include the methionine and folate cycles that are central to cellular function, providing 1C units (methyl groups) for the synthesis of DNA, polyamines, amino acids, creatine, and phospholipids. Sadenosylmethionine is a potent aminopropyl and methyl donor within these cycles and serves as the principal substrate for methylation of DNA, associated proteins, and RNA. We propose that 1C metabolism functions as a key biochemical conduit between parental environment and epigenetic regulation of early development and that interindividual and ethnic variability in epigenetic-gene regulation arises because of genetic variants within 1C genes, associated epigenetic regulators, and differentially methylated target DNA sequences. We present evidence to support these propositions, drawing upon studies undertaken in humans and animals. We conclude that future studies should assess the epigenetic effects of cumulative (multigenerational) dietary imbalances contemporaneously in both parents, as this better represents the human experience.
|Journal Article Type||Article|
|Publication Date||Feb 15, 2019|
|Journal||Annual Review of Animal Biosciences|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Clare, C. E., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2019). One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development. Annual Review of Animal Biosciences, 7(1), doi:10.1146/annurev-animal-020518-115206|
|Keywords||Biotechnology; Animal Science and Zoology; Genetics; General Veterinary|
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