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Pharmacists’ experiences on adverse drug reaction: 10 years later

Karuppannan, Mahmathi; Mohamad Rizal, Nur Azzrin Nisha; Wong, Kok Thong; Mohd. Ali, Salmiah; Ting, Kang Nee; Boardman, Helen

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Mahmathi Karuppannan

Nur Azzrin Nisha Mohamad Rizal

Kok Thong Wong

Salmiah Mohd. Ali

Kang Nee Ting


Adverse drug reaction (ADR) is one of the leading public health concerns associated with high mortality rate. Healthcare professionals, particularly pharmacists, have a significant role in monitoring and preventing ADRs. This study was conducted on Malaysian Pharmaceutical Society (MPS) pharmacists who worked at the hospitals, health clinics, and community pharmacies to determine if pharmacists’ experiences on ADRs are still the same 10years later. In 2010, a postal survey and in 2020, an online survey were conducted among these pharmacists. A total of 472 pharmacists and 208 participated in 2010 and 2020, respectively. About 82% and 90% of hospital/health clinic pharmacists (HCPs) observed an ADR over the last 6 months in 2010 and 2020, while 60% and 100% community pharmacists in 2010 and 2020 observed an ADR, respectively. Perindopril was the top drug (HCPs: p = 0.657; CPs: p = 0.98), and rash was the top ADR reported by the pharmacists in both years (HCPs: p < 0.001; CPs: p = 0.679). The most common actions taken by HCPs in 2010 were to report the ADR (p = 0.343), while in 2020, most HCPs explained to patients regarding the reaction (p = 0.061), which was also the same in the CP group in 2020 (p = 0.958). The top factor encouraging ADR reporting in both years and both pharmacist groups was the high degree of severity of the reaction (HCPs: p < 0.001; CPs: p = 0.769). While the top factors discouraging ADR reporting were a lack of information from the affected patients (HCPs: p = 0.2; CPs: p = 0.656), reaction is widely known (HCPs: p = 0.001; CPs: p = 0.144) and uncertainty of the causal relationship (HCPs: p = 0.169; CPs: p = 0.609). Majority of the pharmacists agreed that severe reactions should be reported (HCPs: p = 0.158; CPs: p = 0.501) and the main aim for reporting is to measure the incidence of ADRs (HCPs: p = 0.148; CPs: p = 0.762). Despite being able to identify ADRs during the daily practice, many pharmacists especially community pharmacists are not reporting them. There is a misconception on the purpose of reporting ADRs. An interventional program and ADR reporting training would be a useful step in improving ADR reporting practice.


Karuppannan, M., Mohamad Rizal, N. A. N., Wong, K. T., Mohd. Ali, S., Ting, K. N., & Boardman, H. (2022). Pharmacists’ experiences on adverse drug reaction: 10 years later. Frontiers in Pharmacology, 13, Article 932942.

Journal Article Type Article
Acceptance Date Aug 24, 2022
Online Publication Date Sep 29, 2022
Publication Date Sep 29, 2022
Deposit Date Oct 18, 2022
Publicly Available Date Oct 18, 2022
Electronic ISSN 1663-9812
Publisher Frontiers Media SA
Peer Reviewed Peer Reviewed
Volume 13
Article Number 932942
Keywords Pharmacology (medical); Pharmacology
Public URL
Publisher URL


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