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The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art

Beddoe, Rhydian H.; Sneddon, Helen F.; Denton, Ross M.


Rhydian H. Beddoe

Helen F. Sneddon

Professor of Organic Chemistry


The Mitsunobu reaction is widely regarded as the pre-eminent method for performing nucleophilic substitutions of alcohols with inversion of configuration. However, its applicability to large-scale synthesis is undermined by the fact that alcohol activation occurs at the expense of two stoichiometric reagents – a phosphine and an azodicarboxylate. The ideal Mitsunobu reaction would be sub-stoichiometric in the phosphine and azodicarboxylate species and employ innocuous terminal oxidants and reductants to achieve recycling. This Review article provides a summary and analysis of recent advances towards the development of such catalytic Mitsunobu reactions.

Journal Article Type Article
Publication Date Nov 14, 2018
Journal Organic & Biomolecular Chemistry
Print ISSN 1477-0520
Electronic ISSN 1477-0539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 42
Issue 16
Pages 7774-7781
APA6 Citation Beddoe, R. H., Sneddon, H. F., & Denton, R. M. (2018). The catalytic Mitsunobu reaction: a critical analysis of the current state-of-the-art. Organic and Biomolecular Chemistry, 42(16), 7774-7781. doi:10.1039/c8ob01929k
Keywords Physical and Theoretical Chemistry; Organic Chemistry; Biochemistry
Publisher URL!divAbstract
Additional Information : This document is Similarity Check deposited; : Rhydian H. Beddoe (ORCID); : Ross M. Denton (ORCID); : Single-blind; : Received 7 August 2018; Accepted 28 September 2018; Accepted Manuscript published 1 October 2018; Advance Article published 11 October 2018


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