Mahdi Nohtani
Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL
Nohtani, Mahdi; Vrzalikova, Katerina; Ibrahim, Maha; Powell, Judith E.; Fennell, Éanna; Morgan, Susan; Grundy, Richard; McCarthy, Keith; Dewberry, Sarah; Bouchal, Jan; Bouchalova, Katerina; Kearns, Pamela; Murray, Paul G.
Authors
Katerina Vrzalikova
Maha Ibrahim
Judith E. Powell
Éanna Fennell
Susan Morgan
RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology
Keith McCarthy
Sarah Dewberry
Jan Bouchal
Katerina Bouchalova
Pamela Kearns
Paul G. Murray
Abstract
In this study, we have re-evaluated how EBV status influences clinical outcome. To accomplish this, we performed a literature review of all studies that have reported the effect of EBV status on patient outcome and also explored the effect of EBV positivity on outcome in a clinical trial of children with cHL from the UK. Our literature review revealed that almost all studies of older adults/elderly patients have reported an adverse effect of an EBV-positive status on outcome. In younger adults with cHL, EBV-positive status was either associated with a moderate beneficial effect or no effect, and the results in children and adolescents were conflicting. Our own analysis of a series of 166 children with cHL revealed no difference in overall survival between EBV-positive and EBV-negative groups (p = 0.942, log rank test). However, EBV-positive subjects had significantly longer event-free survival (p = 0.0026). Positive latent membrane protein 1 (LMP1) status was associated with a significantly lower risk of treatment failure in a Cox regression model (HR = 0.21, p = 0.005). In models that controlled for age, gender, and stage, EBV status had a similar effect size and statistical significance. This study highlights the age-related impact of EBV status on outcome in cHL patients and suggests different pathogenic effects of EBV at different stages of life.
Citation
Nohtani, M., Vrzalikova, K., Ibrahim, M., Powell, J. E., Fennell, É., Morgan, S., …Murray, P. G. (2022). Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL. Cancers, 14(17), Article 4297. https://doi.org/10.3390/cancers14174297
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 16, 2022 |
Online Publication Date | Sep 1, 2022 |
Publication Date | Sep 1, 2022 |
Deposit Date | Nov 9, 2022 |
Publicly Available Date | Nov 9, 2022 |
Journal | Cancers |
Electronic ISSN | 2072-6694 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 17 |
Article Number | 4297 |
DOI | https://doi.org/10.3390/cancers14174297 |
Keywords | Epstein–Barr virus (EBV), classic Hodgkin lymphoma (cHL), clinical trial |
Public URL | https://nottingham-repository.worktribe.com/output/11742982 |
Publisher URL | https://www.mdpi.com/2072-6694/14/17/4297 |
Files
Impact of Tumour Epstein–Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL
(1.2 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Germ-line and somatic DICER1 mutations in pineoblastoma
(2014)
Journal Article
Processed pseudogenes acquired somatically during cancer development
(2014)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search