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Assessing microstructural substrates of white matter abnormalities: a comparative study using DTI and NODDI

Timmers, Inge; Roebroeck, Alard; Bastiani, Matteo; Jansma, Bernadette; Rubio-Gozalbo, Estela; Zhang, Hui

Authors

Inge Timmers

Alard Roebroeck

Bernadette Jansma

Estela Rubio-Gozalbo

Hui Zhang



Contributors

Pew-Thian Yap
Editor

Abstract

Neurite orientation dispersion and density imaging (NODDI) enables more specific characterization of tissue microstructure by estimating neurite density (NDI) and orientation dispersion (ODI), two key contributors to fractional anisotropy (FA). The present work compared NODDI- with diffusion tensor imaging (DTI)-derived indices for investigating white matter abnormalities in a clinical sample. We assessed the added value of NODDI parameters over FA, by contrasting group differences identified by both models. Diffusion-weighted images with multiple shells were acquired in a group of 8 healthy controls and 8 patients with an inherited metabolic disease. Both standard DTI and NODDI analyses were performed. Tract based spatial statistics (TBSS) was used for group inferences, after which overlap and unique contributions across different parameters were evaluated. Results showed that group differences in NDI and ODI were complementary, and together could explain much of the FA results. Further, compared to FA analysis, NDI and ODI gave a pattern of results that was more regionally specific and were able to capture additional discriminative voxels that FA failed to identify. Finally, ODI from single-shell NODDI analysis, but not NDI, was found to reproduce the group differences from the multi-shell analysis. To conclude, by using a clinically feasible acquisition and analysis protocol, we demonstrated that NODDI is of added value to standard DTI, by revealing specific microstructural substrates to white matter changes detected with FA. As the (simpler) DTI model was more sensitive in identifying group differences, NODDI is recommended to be used complementary to DTI, thereby adding greater specificity regarding microstructural underpinnings of the differences. The finding that ODI abnormalities can be identified reliably using single-shell data may allow the retrospective analysis of standard DTI with NODDI.

Journal Article Type Article
Publication Date Dec 21, 2016
Journal PLOS ONE
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 11
Issue 12
Article Number e0167884
APA6 Citation Timmers, I., Roebroeck, A., Bastiani, M., Jansma, B., Rubio-Gozalbo, E., & Zhang, H. (2016). Assessing microstructural substrates of white matter abnormalities: a comparative study using DTI and NODDI. PLoS ONE, 11(12), https://doi.org/10.1371/journal.pone.0167884
DOI https://doi.org/10.1371/journal.pone.0167884
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167884

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