Matteo Bastiani
Automatic segmentation of human cortical layer-complexes and architectural areas using ex vivo diffusion MRI and its validation
Bastiani, Matteo; Oros-Peusquens, Ana-Maria; Seehaus, Arne; Brenner, Daniel; M�llenhoff, Klaus; Celik, Avdo; Felder, J�rg; Bratzke, Hansj�rgen; Shah, Nadim J.; Galuske, Ralf; Goebel, Rainer; Roebroeck, Alard
Authors
Ana-Maria Oros-Peusquens
Arne Seehaus
Daniel Brenner
Klaus M�llenhoff
Avdo Celik
J�rg Felder
Hansj�rgen Bratzke
Nadim J. Shah
Ralf Galuske
Rainer Goebel
Alard Roebroeck
Abstract
Recently, several magnetic resonance imaging contrast mechanisms have been shown to distinguish cortical substructure corresponding to selected cortical layers. Here, we investigate cortical layer and area differentiation by automatized unsupervised clustering of high-resolution diffusion MRI data. Several groups of adjacent layers could be distinguished in human primary motor and premotor cortex. We then used the signature of diffusion MRI signals along cortical depth as a criterion to detect area boundaries and find borders at which the signature changes abruptly. We validate our clustering results by histological analysis of the same tissue. These results confirm earlier studies which show that diffusion MRI can probe layer-specific intracortical fiber organization and, moreover, suggests that it contains enough information to automatically classify architecturally distinct cortical areas. We discuss the strengths and weaknesses of the automatic clustering approach and its appeal for MR-based cortical histology.
Citation
Bastiani, M., Oros-Peusquens, A.-M., Seehaus, A., Brenner, D., Möllenhoff, K., Celik, A., Felder, J., Bratzke, H., Shah, N. J., Galuske, R., Goebel, R., & Roebroeck, A. (2016). Automatic segmentation of human cortical layer-complexes and architectural areas using ex vivo diffusion MRI and its validation. Frontiers in Neuroscience, 10, Article 487. https://doi.org/10.3389/fnins.2016.00487
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 11, 2016 |
Online Publication Date | Nov 10, 2016 |
Publication Date | Nov 10, 2016 |
Deposit Date | Oct 12, 2018 |
Publicly Available Date | Oct 12, 2018 |
Journal | Frontiers in Neuroscience |
Print ISSN | 1662-4548 |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Article Number | 487 |
DOI | https://doi.org/10.3389/fnins.2016.00487 |
Public URL | https://nottingham-repository.worktribe.com/output/1161910 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fnins.2016.00487/full |
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