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Editorial: Lymphatic delivery and targeting of drugs, vaccines, and imaging agents

Han, Sifei; Trevaskis, Natalie; Gershkovich, Pavel; Kagan, Leonid


Sifei Han

Natalie Trevaskis

Leonid Kagan


The lymphatic system plays a key role in the (patho) physiology of a number of diseases, including autoimmune/inflammatory disorders, cancer, infections, and metabolic syndrome. Biological pathways in the lymphatic system provide new promising treatment targets for several conditions (Oliver, Kipnis et al., 2020; Petrova and Koh 2020). However, most molecules, including imaging and therapeutic agents, exhibit poor access to the lymphatics which impedes research of the lymphatic system and development of related therapies (Trevaskis, Kaminskas et al., 2015). In this Research Topic, we present a collection of primary research articles that provide new insights into the physiology of lymphatics and lymph-directed drug delivery, as well as review articles that summarize the approaches used to improve lymphatic targeting of imaging agents and drugs.


Han, S., Trevaskis, N., Gershkovich, P., & Kagan, L. (2022). Editorial: Lymphatic delivery and targeting of drugs, vaccines, and imaging agents. Frontiers in Pharmacology, 13, Article 1011778.

Journal Article Type Editorial
Acceptance Date Aug 12, 2022
Online Publication Date Sep 2, 2022
Publication Date Sep 2, 2022
Deposit Date Dec 13, 2022
Publicly Available Date Sep 2, 2022
Journal Frontiers in Pharmacology
Electronic ISSN 1663-9812
Publisher Frontiers Media SA
Peer Reviewed Peer Reviewed
Volume 13
Article Number 1011778
Keywords Pharmacology, Drug delivery, lymphatics, imaging, macromolecules, nanomedicine, immunotherapy
Public URL
Publisher URL
Additional Information Received: 04 August 2022; Accepted: 12 August 2022; Published: 02 September 2022.


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