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Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

Ma, Chenhui; Han, Li; Zhu, Zheying; Heng Pang, Cheng; Pan, Guoyu

Authors

Chenhui Ma

Li Han

ZHEYING ZHU Zheying.Zhu@nottingham.ac.uk
Associate Professor in International Pharmacy and Traditional Medicines

Cheng Heng Pang

Guoyu Pan



Abstract

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential role in various biochemical processes. Moreover, the identification of ferroptosis and cuproptosis further underscores the importance of intracellular mineral homeostasis. However, perturbation of minerals has been frequently reported in patients with NAFLD and related diseases. Interestingly, studies have attempted to establish an association between mineral disorders and NAFLD pathological features, including oxidative stress, mitochondrial dysfunction, inflammatory response, and fibrogenesis. In this review, we aim to provide an overview of the current understanding of mineral metabolism (i.e., absorption, utilization, and transport) and mineral interactions in the pathogenesis of NAFLD. More importantly, this review highlights potential therapeutic strategies, challenges, future directions for targeting mineral metabolism in the treatment of NAFLD.

Citation

Ma, C., Han, L., Zhu, Z., Heng Pang, C., & Pan, G. (2022). Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases. Biochemical Pharmacology, 205, Article 115242. https://doi.org/10.1016/j.bcp.2022.115242

Journal Article Type Article
Acceptance Date Aug 30, 2022
Online Publication Date Sep 7, 2022
Publication Date Nov 1, 2022
Deposit Date Sep 13, 2022
Publicly Available Date Sep 8, 2023
Journal Biochemical Pharmacology
Print ISSN 0006-2952
Electronic ISSN 1873-2968
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 205
Article Number 115242
DOI https://doi.org/10.1016/j.bcp.2022.115242
Keywords Iron, Non-alcoholic steatohepatitis, Non-alcoholic fatty liver disease, Copper, Mineral, Ferroptosis
Public URL https://nottingham-repository.worktribe.com/output/11193748
Publisher URL https://www.sciencedirect.com/science/article/pii/S0006295222003367?via%3Dihub
Additional Information This article is maintained by: Elsevier; Article Title: Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases; Journal Title: Biochemical Pharmacology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.bcp.2022.115242; Content Type: article.

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