Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

Ma, Chenhui; Han, Li; Zhu, Zheying; Heng Pang, Cheng; Pan, Guoyu

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential role in various biochemical processes. Moreover, the identification of ferroptosis and cuproptosis further underscores the importance of intracellular mineral homeostasis. However, perturbation of minerals has been frequently reported in patients with NAFLD and related diseases. Interestingly, studies have attempted to establish an association between mineral disorders and NAFLD pathological features, including oxidative stress, mitochondrial dysfunction, inflammatory response, and fibrogenesis. In this review, we aim to provide an overview of the current understanding of mineral metabolism (i.e., absorption, utilization, and transport) and mineral interactions in the pathogenesis of NAFLD. More importantly, this review highlights potential therapeutic strategies, challenges, future directions for targeting mineral metabolism in the treatment of NAFLD.

Citation

Ma, C., Han, L., Zhu, Z., Heng Pang, C., & Pan, G. (2022). Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases. Biochemical Pharmacology, 205, Article 115242. https://doi.org/10.1016/j.bcp.2022.115242

• Journal Article Type: Article
• Acceptance Date: Aug 30, 2022
• Online Publication Date: Sep 7, 2022
• Publication Date: Nov 1, 2022
• Deposit Date: Sep 13, 2022
• Publicly Available Date: Sep 8, 2023
• Journal: Biochemical Pharmacology
• Print ISSN: 0006-2952
• Electronic ISSN: 1873-2968
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 205
• Article Number: 115242
• DOI: https://doi.org/10.1016/j.bcp.2022.115242
• Keywords: Iron, Non-alcoholic steatohepatitis, Non-alcoholic fatty liver disease, Copper, Mineral, Ferroptosis
• Public URL: https://nottingham-repository.worktribe.com/output/11193748
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0006295222003367?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases; Journal Title: Biochemical Pharmacology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.bcp.2022.115242; Content Type: article.