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Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies

Ding, Tamir; Spendlove, Ian; Durrant, Lindy G.; Scott, Andrew M.; Yuriev, Elizabeth; Ramsland, Paul A.

Authors

Tamir Ding

Lindy G. Durrant

Andrew M. Scott

Elizabeth Yuriev

Paul A. Ramsland



Abstract

Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy.

Citation

Ding, T., Spendlove, I., Durrant, L. G., Scott, A. M., Yuriev, E., & Ramsland, P. A. (2015). Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies. Molecular Immunology, 67(2, Pt. A), 75-88. doi:10.1016/j.molimm.2015.02.028

Journal Article Type Article
Acceptance Date Feb 19, 2015
Online Publication Date Mar 7, 2015
Publication Date Oct 31, 2015
Deposit Date Jun 7, 2018
Electronic ISSN 1872-9142
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 67
Issue 2, Pt. A
Pages 75-88
DOI https://doi.org/10.1016/j.molimm.2015.02.028
Public URL https://nottingham-repository.worktribe.com/output/1112439
Publisher URL https://www.sciencedirect.com/science/article/pii/S0161589015000772?via%3Dihub
PMID 25757815