Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences

Cousins, Alex R.O.; Searle, Mark S.; Ritson, Dougal; Sharma, Pallavi; Stevens, Malcolm F.G.; Moses, John E.

Abstract

© The Royal Society of Chemistry 2014. Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.

Citation

Cousins, A. R., Searle, M. S., Ritson, D., Sharma, P., Stevens, M. F., & Moses, J. E. (2014). Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences. Chemical Communications, 50(96), 15202-15205. https://doi.org/10.1039/c4cc07487d

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2014
• Online Publication Date: Oct 23, 2014
• Publication Date: Oct 23, 2014
• Deposit Date: Jul 6, 2017
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Issue: 96
• Pages: 15202-15205
• DOI: https://doi.org/10.1039/c4cc07487d
• Public URL: https://nottingham-repository.worktribe.com/output/1110306
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2014/CC/C4CC07487D#!divAbstract
• PMID: 00034499
• Additional Information: : This document is CrossCheck deposited; : The Royal Society of Chemistry has an exclusive publication licence for this journal; : Received 23 September 2014; Accepted 17 October 2014; Advance Article published 23 October 2014; Version of Record published 6 November 2014