Imaging Angiogenesis, Inflammation, and Metastasis in the Tumor Microenvironment with Magnetic Resonance Imaging

O�Brien, Emma R.; Serres, Sebastien; Sibson, Nicola R.

Abstract

With the development of new imaging techniques, the potential for probing the molecular, cellular, and structural components of the tumor microenvironment in situ has increased dramatically. A multitude of imaging modalities have been successfully employed to probe different aspects of the tumor microenvironment, including expression of molecules, cell motion, cellularity, vessel permeability, vascular perfusion, metabolic and physiological changes, apoptosis, and inflammation. This chapter focuses on the most recent advances in magnetic resonance imaging methods, which offer a number of advantages over other methodologies, including high spatial resolution and the use of nonionizing radiation, as well as the use of such methods in the context of primary and secondary brain tumors. It also highlights how they can be used to assess the molecular and cellular changes in the tumor microenvironment in response to therapy.

Citation

O’Brien, E. R., Serres, S., & Sibson, N. R. (2013). Imaging Angiogenesis, Inflammation, and Metastasis in the Tumor Microenvironment with Magnetic Resonance Imaging. In Tumor Microenvironment and Cellular Stress (263-283). Springer New York. https://doi.org/10.1007/978-1-4614-5915-6_12

• Online Publication Date: Oct 23, 2013
• Publication Date: Nov 24, 2013
• Deposit Date: Mar 8, 2017
• Electronic ISSN: 2214-8019
• Peer Reviewed: Peer Reviewed
• Pages: 263-283
• Series Title: Advances in Experimental Medicine and Biology
• Series Number: 772
• Book Title: Tumor Microenvironment and Cellular Stress
• ISBN: 9781461459149
• DOI: https://doi.org/10.1007/978-1-4614-5915-6_12
• Public URL: http://www.ncbi.nlm.nih.gov/pubmed/24272363
• Publisher URL: https://link.springer.com/chapter/10.1007%2F978-1-4614-5915-6_12
• Contract Date: Oct 23, 2018