Biological characteristics and clinical outcome of triple negative primary breast cancer in older women - comparison with their younger counterparts.

Syed, Binafsha M.; Green, Andrew R.; Nolan, Christopher C.; Morgan, David A.L.; Ellis, Ian O.; Cheung, Kwok-Leung

Abstract

Triple negative (ER, PgR and HER2 negative) breast cancers (TNBCs) are often considered as a poor prognostic phenotype. There is dearth of evidence showing the prevalence and biological behaviour of TNBCs in older women. This study aimed to analyse their biological characteristics in comparison with a well characterised younger series from a single centre with long term clinical follow-up. Over 37 years (1973–2010), 1,758 older (≥70 years) women with early operable (

• Journal Article Type: Article
• Acceptance Date: May 26, 2014
• Publication Date: Jul 7, 2014
• Deposit Date: Sep 7, 2018
• Publicly Available Date: Oct 18, 2018
• Journal: PLoS ONE
• Electronic ISSN: 1932-6203
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 7
• Article Number: e10057
• DOI: https://doi.org/10.1371/journal.pone.0100573
• Public URL: https://nottingham-repository.worktribe.com/output/1098192
• Publisher URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100573
• PMID: 24999743
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