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Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review

Prayuenyong, Pattarawadee; Taylor, John A.; Pearson, Stephanie E.; Gomez, Rachel; Patel, Poulam M.; Hall, Deborah A.; Kasbekar, Anand V.; Baguley, David M.

Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review Thumbnail


Authors

Pattarawadee Prayuenyong

John A. Taylor

Stephanie E. Pearson

RACHEL GOMES rachel.gomes@nottingham.ac.uk
Professor of Water & Resource Processing

POULAM PATEL POULAM.PATEL@NOTTINGHAM.AC.UK
Professor of Clinical Oncology

Deborah A. Hall

Anand V. Kasbekar

David M. Baguley



Abstract

Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer.
Methods: Inclusion criteria followed the PICO principles: Participants, adult and paediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects. English language articles published since 1978 were retrieved. Seventy-five eligible studies were identified from a systematic literature search, and relevant data were charted, collated, and summarized.
Results: Testing for vestibulotoxicity predominately featured functional evaluation of the horizontal semicircular canal using the caloric and rotational tests. The rate of abnormal vestibular function test results after chemotherapy administration varied from 0-50%. The results of objective testing did not always correspond to patient symptoms. There is tentative support for patients with pre-existing loss of vestibular function to be more likely to experience vestibular toxicity after dosing with cisplatin.
Conclusions: A number of studies reported significant evidence of vestibular toxicities associated with platinum-based chemotherapy, especially cisplatin. This scoping review emphasizes that vestibular toxicity needs more attention and comprehensive evaluation. Specifically, studies that analyse cumulative dose of platinum-based chemotherapy, affected sites of lesion in vestibular end organs, and the correlation and temporal patterns of cochlear and vestibular toxicity are needed.

Citation

Prayuenyong, P., Taylor, J. A., Pearson, S. E., Gomez, R., Patel, P. M., Hall, D. A., …Baguley, D. M. (2018). Vestibulotoxicity associated with platinum-based chemotherapy in survivors of cancer: a scoping review. Frontiers in Oncology, 8, Article 363. https://doi.org/10.3389/fonc.2018.00363

Journal Article Type Article
Acceptance Date Aug 16, 2018
Publication Date Sep 25, 2018
Deposit Date Sep 11, 2018
Publicly Available Date Mar 28, 2024
Electronic ISSN 2234-943X
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 8
Article Number 363
DOI https://doi.org/10.3389/fonc.2018.00363
Keywords Vestibulotoxicity, vestibular, adverse effect, Platinum-based chemotherapy, Cancer
Public URL https://nottingham-repository.worktribe.com/output/1069897
Publisher URL https://www.frontiersin.org/articles/10.3389/fonc.2018.00363/full