Sulfonimidates: useful synthetic intermediates for sulfoximine synthesis via C–S bond formation

Matos, Priscilla Mendon�a; Lewis, William; Moore, Jonathan C.; Stockman, Robert A.

Abstract

The ever-increasing prevalence of sulfoximine derivatives in drug discovery programmes has brought about a renaissance in the development of methods for their synthesis. Sulfoximine synthesis via C-S bond formation however has been comparatively underexplored. Herein, we report that sulfonimidates constitute a versatile precursor for the synthesis of medicinally relevant sulfoximines.

Citation

Matos, P. M., Lewis, W., Moore, J. C., & Stockman, R. A. (2018). Sulfonimidates: useful synthetic intermediates for sulfoximine synthesis via C–S bond formation. Organic Letters, 20(12), 3674-3677. https://doi.org/10.1021/acs.orglett.8b01473

• Journal Article Type: Article
• Acceptance Date: Jun 7, 2018
• Online Publication Date: Jun 7, 2018
• Publication Date: Jun 15, 2018
• Deposit Date: Aug 20, 2018
• Publicly Available Date: Jun 8, 2019
• Journal: Organic Letters
• Print ISSN: 1523-7060
• Electronic ISSN: 1523-7052
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 12
• Pages: 3674-3677
• DOI: https://doi.org/10.1021/acs.orglett.8b01473
• Public URL: https://nottingham-repository.worktribe.com/output/1038568
• Publisher URL: https://pubs.acs.org/doi/10.1021/acs.orglett.8b01473
• Contract Date: Aug 20, 2018