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Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop

Bell, R. M.; Basalay, M.; Bøtker, H. E.; Beikoghli Kalkhoran, S.; Carr, R. D.; Cunningham, J.; Davidson, S. M.; England, T. J.; Giesz, S.; Ghosh, A. K.; Golforoush, P.; Gourine, A. V.; Hausenloy, D. J.; Heusch, G.; Ibanez, B.; Kleinbongard, P.; Lecour, S.; Lukhna, K.; Ntsekhe, M.; Ovize, M.; Salama, A. D.; Vilahur, G.; Walker, J. M.; Yellon, D. M.


R. M. Bell

M. Basalay

H. E. Bøtker

S. Beikoghli Kalkhoran

R. D. Carr

J. Cunningham

S. M. Davidson

S. Giesz

A. K. Ghosh

P. Golforoush

A. V. Gourine

D. J. Hausenloy

G. Heusch

B. Ibanez

P. Kleinbongard

S. Lecour

K. Lukhna

M. Ntsekhe

M. Ovize

A. D. Salama

G. Vilahur

J. M. Walker

D. M. Yellon


The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2–ERIC–PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely due to the disconnect between preclinical and clinical studies. Discussion points included how to adapt preclinical animal studies to mirror the patient presenting with an acute myocardial infarction, as well as how to refine patient selection in clinical studies to account for co-morbidities and ongoing therapy. These latter scenarios can modify cytoprotective signalling and need to be taken into account to allow for a more robust outcome when powered appropriately. The workshop also discussed the potential for RIC in other disease settings including ischaemic stroke, cardio-oncology and COVID-19. The workshop, therefore, put forward specific classifications which could help identify so-called responders vs. non-responders in both the preclinical and clinical settings.


Bell, R. M., Basalay, M., Bøtker, H. E., Beikoghli Kalkhoran, S., Carr, R. D., Cunningham, J., …Yellon, D. M. (2022). Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop. Basic Research in Cardiology, 117, Article 39.

Journal Article Type Article
Acceptance Date Aug 3, 2022
Online Publication Date Aug 15, 2022
Publication Date Aug 15, 2022
Deposit Date Oct 21, 2022
Publicly Available Date Oct 21, 2022
Journal Basic Research in Cardiology
Print ISSN 0300-8428
Electronic ISSN 1435-1803
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 117
Article Number 39
Keywords Physiology (medical); Cardiology and Cardiovascular Medicine; Physiology
Public URL
Publisher URL


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