Amy R. Donaldson
Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells
Donaldson, Amy R.; Edi Tanase, Constantin; Awuah, Dennis; Vasanthi Bathri Narayanan, Pranav; Hall, Laurence; Nikkhah, Mehdi; Khademhosseini, Ali; Rose, Felicity; Alexander, Cameron; Ghaemmaghami, Amir M.
Authors
Constantin Edi Tanase
Dennis Awuah
Pranav Vasanthi Bathri Narayanan
Laurence Hall
Mehdi Nikkhah
Ali Khademhosseini
FELICITY ROSE FELICITY.ROSE@NOTTINGHAM.AC.UK
Professor of Biomaterials and Tissue Engineering
Professor CAMERON ALEXANDER CAMERON.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Polymer Therapeutics
Professor AMIR GHAEMMAGHAMI AMIR.GHAEMMAGHAMI@NOTTINGHAM.AC.UK
Professor of Immunology and Immuno- Bioengineering
Abstract
Hydrogels are an attractive class of biomaterials in tissue engineering due to their inherently compatible properties for cell culture. Gelatin methacryloyl (GelMA) has shown significant promise in the fields of tissue engineering and drug delivery, as its physical properties can be precisely tuned depending on the specific application. There is a growing appreciation for the interaction between biomaterials and cells of the immune system with the increasing usage of biomaterials for in vivo applications. Here, we addressed the current lack of information regarding the immunogenicity of photocrosslinked GelMA. We investigated the ability of human mononuclear cells to mount inflammatory responses in the context of a GelMA hydrogel platform. Using lipopolysaccharide to stimulate a pro-inflammatory immune response, we found tumour necrosis factor-α (TNF-α) expression was suppressed in GelMA culture conditions. Our findings have important implications on the future use of GelMA and highlight the significance of investigating the potential immune-modulatory properties of biomaterials.
Citation
Donaldson, A. R., Edi Tanase, C., Awuah, D., Vasanthi Bathri Narayanan, P., Hall, L., Nikkhah, M., …Ghaemmaghami, A. M. (2018). Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells. Frontiers in Bioengineering and Biotechnology, 6, Article 116. https://doi.org/10.3389/fbioe.2018.00116
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 27, 2018 |
Publication Date | Sep 19, 2018 |
Deposit Date | Aug 14, 2018 |
Publicly Available Date | Sep 19, 2018 |
Electronic ISSN | 2296-4185 |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Article Number | 116 |
DOI | https://doi.org/10.3389/fbioe.2018.00116 |
Keywords | Hydrogels, Tumor Necrosis Factors, Immune Modulation, PBMCs, Immune Regulation, Gelatin |
Public URL | https://nottingham-repository.worktribe.com/output/1031290 |
Files
fbioe-06-00116
(1.7 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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