Adam S. Dawe
Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans
Dawe, Adam S.; Nylund, Reeta; Leszczynski, Dariusz; Kuster, Niels; Reader, Tom; de Pomerai, David I.
Authors
Reeta Nylund
Dariusz Leszczynski
Niels Kuster
TOM READER TOM.READER@NOTTINGHAM.AC.UK
Associate Professor
David I. de Pomerai
Abstract
Recent data suggest that there might be a subtle thermal explanation for the apparent induction by radiofrequency (RF) radiation of transgene expression from a small-heat-shock-protein (hsp16-1) promoter in the nematode, Caenorhabditis elegans. The RF fields used in the C. elegans study were much weaker (SAR 5-40 mW kg-1) than those routinely tested in many other published studies (SAR ~2 W kg-1). To resolve this disparity, we have exposed the same transgenic hsp16-1::lacZ strain of C. elegans (PC72) to higher intensity RF fields (1.8 GHz; SAR ~1.8 W kg-1). For both continuous wave (CW) and Talk-pulsed RF exposures (2.5 h at 25C), there was no indication that RF exposure could induce reporter expression above sham control levels. Thus, at much higher induced RF field strength (close to the maximum permitted exposure from a mobile telephone handset), this particular nematode heat-shock gene is not up-regulated. However, under conditions where background reporter expression was moderately elevated in the sham controls (perhaps as a result of some unknown co-stressor), we found some evidence that reporter expression may be reduced by ~15% following exposure to either Talk-pulsed or CW RF fields.
Citation
Dawe, A. S., Nylund, R., Leszczynski, D., Kuster, N., Reader, T., & de Pomerai, D. I. (2008). Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans. Bioelectromagnetics, 29(2), https://doi.org/10.1002/bem.20366
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2008 |
Deposit Date | Jun 14, 2013 |
Publicly Available Date | Jun 14, 2013 |
Journal | Bioelectromagnetics |
Print ISSN | 0197-8462 |
Electronic ISSN | 1521-186X |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 2 |
DOI | https://doi.org/10.1002/bem.20366 |
Public URL | https://nottingham-repository.worktribe.com/output/1015665 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1002/bem.20366/abstract |
Additional Information | The definitive version is available at www3.interscience.wiley.com |
Files
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