Outputs (14)

Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care (2024)
Journal Article
Kanchau, J. D., Akyea, R. K., Baharudin, N., Mohamed-Yassin, M., Kamal, A., Chua, Y., …Ramli, A. S. (2024). Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care. Clinical Epidemiology and Global Health, 27, Article 101619. https://doi.org/10.1016/j.cegh.2024.101619

Background Adults with severely elevated low-density lipoprotein cholesterol (LDL-c) may have familial hypercholesterolaemia (FH) and are at high risk of atherosclerotic cardiovascular disease (ASCVD). The prevalence of elevated LDL-c in primary car... Read More about Prevalence and distributions of severely elevated low-density lipoprotein cholesterol (LDL-c) according to age, gender and clinic location among patients in the Malaysian primary care.

A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care (2024)
Journal Article
Abdul-Halim, M. A. Z., Abdul-Hamid, H., Baharudin, N., Mohamed-Yassin, M., Kasim, S. S., Nawawi, H., …Ramli, A. S. (2024). A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care. European Heart Journal: Case Reports, 8(2), Article ytae039. https://doi.org/10.1093/ehjcr/ytae039

Background: Familial hypercholesterolaemia (FH) is an autosomal dominant genetic condition predominantly caused by the low-density lipoprotein receptor (LDLR) gene mutation. Case summary: This is the case of a 54-year-old Malay woman with genetically... Read More about A case report of heterozygous familial hypercholesterolaemia with LDLR gene mutation complicated by premature coronary artery disease detected in primary care.

Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective (2024)
Journal Article
Ng, W. L., Hussein, N., Ng, C. J., Qureshi, N., Lee, Y. K., Kwan, Z., …Azmi, S. U. F. (2024). Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective. PLoS ONE, 19(1), e0296498. https://doi.org/10.1371/journal.pone.0296498

Introduction Allopurinol, the first-line treatment for chronic gout, is a common causative drug for severe cutaneous adverse reactions (SCAR). HLA-B*58:01 allele was strongly associated with allopurinol-induced SCAR in Asian countries such as Taiwan,... Read More about Implementing HLA-B*58:01 testing prior to allopurinol initiation in Malaysian primary care setting: A qualitative study from doctors’ and patients’ perspective.

Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021) (2023)
Journal Article
Chalitsios, C. V., Akyea, R. K., Abdul-Hamid, H., Leonardi-Bee, J., Kanchau, J. D., Kamal, A., …Qureshi, N. (2023). Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021). International Journal of General Medicine, 2023(16), 5885—5888. https://doi.org/10.2147/IJGM.S423091

Cardiovascular disease (CVD) is the leading cause of death worldwide. Hypercholesterolaemia, especially higher low-density lipoprotein cholesterol (LDL-c), has been recognised as one of the major key risk factors for CVD. Lipid lowering treatments, s... Read More about Age and sex differences in LDL cholesterol distribution in adults in Malaysia: A cross-sectional study (2010 -2021).

Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London (2023)
Journal Article
Molokhia, M., Wierzbicki, A., Williams, H., Kirubakaran, A., Devani, R., Durbaba, S., …Qureshi, N. (2023). Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London. Atherosclerosis, 388, Article 117353. https://doi.org/10.1016/j.atherosclerosis.2023.117353

Background and aims: Differences in the perceived prevalence of familial hypercholesterolemia (FH) by ethnicity are unclear. In this study, we aimed to assess the prevalence, determinants and management of diagnostically-coded FH in an ethnically div... Read More about Assessment of ethnic inequalities in diagnostic coding of familial hypercholesterolaemia (FH): A cross-sectional database study in Lambeth, South London.

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis (2023)
Journal Article
Qureshi, N., Woods, B., Neves de Faria, R., Saramago Goncalves, P., Cox, E., Leonardi Bee, J., …Kai, J. (2023). Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis. Health Technology Assessment, 27(16), https://doi.org/10.3310/CTMD0148

Background Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia. The cascade-testing protocol starts with identifying an index patient with familial hyperc... Read More about Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis.

A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach (2023)
Journal Article
Akyea, R. K., Ntaios, G., Kontopantelis, E., Georgiopoulos, G., Soria, D., Asselbergs, F. W., …Qureshi, N. (2023). A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach. PLOS Digital Health, 2(9), Article e0000334. https://doi.org/10.1371/journal.pdig.0000334

Individuals developing stroke have varying clinical characteristics, demographic, and biochemical profiles. This heterogeneity in phenotypic characteristics can impact on cardiovascular disease (CVD) morbidity and mortality outcomes. This study uses... Read More about A population-based study exploring phenotypic clusters and clinical outcomes in stroke using unsupervised machine learning approach.

Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region (2023)
Journal Article
Chan, A. Y., Chan, V. K., Bahmanyar, S., Beyene, K., Bushnell, G., Carleton, B., …Wong, I. C. K. Multinational prescribing trends of lithium from 2001 to 2019: a retrospective observational study using population-based databases from 17 countries and one special administrative region. Manuscript submitted for publication

Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE) (2023)
Journal Article
Ogliari, G., Ryg, J., Andersen-Ranberg, K., Scheel-Hincke, L. L., Collins, J. T., Cowley, A., …Masud, T. (2023). Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). European Geriatric Medicine, 14(5), 1111-1124. https://doi.org/10.1007/s41999-023-00835-5

Purpose To investigate the longitudinal associations between pain and depressive symptoms in adults. Methods Prospective cohort study on data from 28,515 community-dwelling adults ≥ 50 years, free from depression at baseline (Wave 5), with follo... Read More about Association between pain intensity and depressive symptoms in community-dwelling adults: longitudinal findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).

UK research data resources based on primary care electronic health records: review and summary for potential users (2023)
Journal Article
Edwards, L., Pickett, J., Ashcroft, D. M., Dambha-Miller, H., Majeed, A., Mallen, C., …MacLeod, J. (2023). UK research data resources based on primary care electronic health records: review and summary for potential users. BJGP Open, 7(3), Article 0057. https://doi.org/10.3399/bjgpo.2023.0057

Objectives To describe the current landscape of UK electronic health record (EHR) databases and considerations of access and use of these resources relevant to researchers. Design & setting Narrative review Data sources Information was collecte... Read More about UK research data resources based on primary care electronic health records: review and summary for potential users.