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Outputs (246)

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study (2023)
Journal Article
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L.-P., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Harris, V. C., Houchen-Wolloff, L., Saunders, R. M., Greening, N. J., Richardson, M., Quint, J. K., Briggs, A., Docherty, A. B., …Behalf of the PHOSP-COVID Collaborative Group, O. (2024). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1), Article dyad165. https://doi.org/10.1093/ije/dyad165

The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.

PHOSP-COVID was established to investigate the medium- and long-term sequel... Read More about Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study.

Can angiotropism and lymphovascular invasion refine the current cutaneous melanoma staging system? (2023)
Journal Article
Namubiru, P., Dalleywater, W., Lashin, S., & Elsheikh, S. (2024). Can angiotropism and lymphovascular invasion refine the current cutaneous melanoma staging system?. Journal of Cutaneous Pathology, 51(4), 288-298. https://doi.org/10.1111/cup.14561

Background: Several prognostic factors for primary cutaneous melanoma (PCM) have been identified, and these predict metastasis and survival, to a certain extent. We sought to determine the frequency of angiotropism (AT) and lymphovascular invasion (L... Read More about Can angiotropism and lymphovascular invasion refine the current cutaneous melanoma staging system?.

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth (2023)
Journal Article
Coleman, D. J., Keane, P., Luque-Martin, R., Chin, P. S., Blair, H., Ames, L., …Bonifer, C. (2023). Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth. Cell Reports, 42(12), Article 113568. https://doi.org/10.1016/j.celrep.2023.113568

Acute myeloid leukemia (AML) is a heterogeneous disease caused by different mutations. Previously, we showed that each mutational subtype develops its specific gene regulatory network (GRN) with transcription factors interacting within multiple gene... Read More about Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth.

Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma (2023)
Journal Article
Burrows, L., Sculthorpe, D., Zhang, H., Rehman, O., Mukherjee, A., & Chen, K. (2024). Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma. Journal of Pathology Informatics, 15, Article 100351. https://doi.org/10.1016/j.jpi.2023.100351

Whilst automated analysis of immunostains in pathology research has focused predominantly on the epithelial compartment, automated analysis of stains in the stromal compartment is challenging and therefore requires time-consuming pathological input a... Read More about Mathematical modelling and deep learning algorithms to automate assessment of single and digitally multiplexed immunohistochemical stains in tumoural stroma.

Understanding recent advances in genomic testing in paediatric oncology (2023)
Journal Article
Robinson, S. L., Seneviratne, N., & Dandapani, M. (2024). Understanding recent advances in genomic testing in paediatric oncology. Paediatrics and Child Health, 34(2), 43-48. https://doi.org/10.1016/j.paed.2023.11.001

Advancements in genomics have had a significant impact on our ability to diagnose and treat several health conditions, notably cancer. In this article, we discuss the evolution of genomic methods from the early first-generation genome sequencing meth... Read More about Understanding recent advances in genomic testing in paediatric oncology.

Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance (2023)
Journal Article
Makhlouf, S., Quinn, C., Toss, M., Alsaleem, M., Atallah, N. M., Ibrahim, A., …Rakha, E. A. (2024). Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance. European Journal of Cancer, 197, Article 113473. https://doi.org/10.1016/j.ejca.2023.113473

Background

Oestrogen receptor (ER) positive breast cancer (BC) patients are eligible for endocrine therapy (ET), regardless of ER immunohistochemical expression level. There is a wide spectrum of ER expression and the response to ET is not uniform... Read More about Quantitative expression of oestrogen receptor in breast cancer: Clinical and molecular significance.

Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England (2023)
Journal Article
Morton, A. J., Simpson, A., & Humes, D. J. (2024). Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England. Techniques in Coloproctology, 28(1), Article 9. https://doi.org/10.1007/s10151-023-02874-3

Background: Laparoscopic and now robotic colorectal surgery has rapidly increased in prevalence; however, little is known about how uptake varies by region and sociodemographics. The aim of this study was to quantify the uptake of minimally invasive... Read More about Regional variations and deprivation are linked to poorer access to laparoscopic and robotic colorectal surgery: a national study in England.

Richter's transformation: Transforming the clinical landscape (2023)
Journal Article
Barrett, A., Appleby, N., Dreau, H., Fox, C., Munir, T., & Eyre, T. (2024). Richter's transformation: Transforming the clinical landscape. Blood Reviews, 64, Article 101163. https://doi.org/10.1016/j.blre.2023.101163

Richter transformation (RT) represents an aggressive histological transformation from chronic lymphocytic leukaemia, most often to a large B cell lymphoma. It is characterised by chemo-resistance and subsequent short survival. Drug development has st... Read More about Richter's transformation: Transforming the clinical landscape.

Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease (2023)
Journal Article
Munir, T., Cairns, D. A., Bloor, A., Allsup, D., Cwynarski, K., Pettitt, A., Paneesha, S., Fox, C. P., Eyre, T. A., Forconi, F., Elmusharaf, N., Kennedy, B., Gribben, J., Pemberton, N., Sheehy, O., Preston, G., Schuh, A., Walewska, R., Duley, L., Howard, D., …Hillmen, P. (2024). Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease. New England Journal of Medicine, 390(4), 326-337. https://doi.org/10.1056/nejmoa2310063

BACKGROUND: The combination of ibrutinib and venetoclax has been shown to improve outcomes in patients with chronic lymphocytic leukemia (CLL) as compared with chemoimmunotherapy. Whether ibrutinib-venetoclax and personalization of treatment duration... Read More about Chronic Lymphocytic Leukemia Therapy Guided by Measurable Residual Disease.