Outputs (7)

Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy (2024)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mather, M. L., Alsaleem, M., Bateman-Price, T. D., Patke, R., Ball, G., Mongan, N. P., & Rakha, E. (2025). Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy. Journal of Microscopy, 297(2), 135-152. https://doi.org/10.1111/jmi.13361

Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of the tumour stroma in BC remains to be defined. Di... Read More about Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.

The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes (2024)
Journal Article
Ghannam, S. F., Makhlouf, S., Alsaleem, M., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. A. (2024). The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes. Modern Pathology, 37(12), Article 100607. https://doi.org/10.1016/j.modpat.2024.100607

The tumor microenvironment plays a key role in tumor progression. The proportion of the stroma-to-tumor cells (stroma-tumor ratio [STR]) has a variable prognostic significance in breast cancer (BC) molecular classes. In this study, we evaluated the m... Read More about The Conflicting Prognostic Role of the Stroma–Tumor Ratio in Breast Cancer Molecular Subtypes.

NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2 (2024)
Journal Article
Cardenas, R. P., Zyoud, A., McIntyre, A., Alberio, R., Mongan, N. P., & Allegrucci, C. (2024). NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2. Stem Cell Research and Therapy, 15(1), Article 128. https://doi.org/10.1186/s13287-024-03724-1

Background
Testicular germ cell tumours (TGCTs) represent a clinical challenge; they are most prevalent in young individuals and are triggered by molecular mechanisms that are not fully understood. The origin of TGCTs can be traced back to primordia... Read More about NANOG controls testicular germ cell tumour stemness through regulation of MIR9-2.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., Peffers, M. J., Mongan, N. P., Arkill, K. P., Ritchie, A., Clarke, P. A., Ratan, H., Allegrucci, C., Grabowska, A. M., & James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression (2023)
Journal Article
Atallah, N. M., Haque, M., Quinn, C., Toss, M. S., Makhlouf, S., Ibrahim, A., Green, A. R., Alsaleem, M., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. European Journal of Cancer, 195, Article 113371. https://doi.org/10.1016/j.ejca.2023.113371

Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a comprehensive clinico-pathological and molecular profile of... Read More about Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression.

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?. Histopathology, 83(3), 376-393. https://doi.org/10.1111/his.14939

Background
Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Preprint / Working Paper
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. A. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?

Background Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule‐like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and t... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.