Outputs (2)

TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. Immunobiology, 228(5), Article 152706. https://doi.org/10.1016/j.imbio.2023.152706

Ischaemic stroke, accompanied by neuroinflammation, impairs blood–brain barrier (BBB) integrity through a complex mechanism involving activation of both RhoA/Rho kinase/myosin light chain-2 and neurokinin 1 receptor (NK1R). Using an in vitro model of... Read More about TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor.

Substance P reversibly compromises the integrity and function of blood-brain barrier (2023)
Journal Article
Gao, X., & Bayraktutan, U. (2023). Substance P reversibly compromises the integrity and function of blood-brain barrier. Peptides, 167, Article 171048. https://doi.org/10.1016/j.peptides.2023.171048

Background
Substance P (SP) plays a role in vasodilatation and tissue integrity through its receptor, neurokinin 1 (NK1R). However, its specific effect on blood-brain barrier (BBB) remains unknown.

Methods
The impact of SP on the integrity/funct... Read More about Substance P reversibly compromises the integrity and function of blood-brain barrier.