Outputs (3)

Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights (2024)
Journal Article
Smith, F., Kotowska, A. M., Fiedler, B., Cerny, E., Cheung, K., Rutland, C. S., Chowdhury, F., Segal, J., Rawson, F. J., & Marlow, M. (2025). Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights. Molecular Pharmaceutics, 22(1), 316-329. https://doi.org/10.1021/acs.molpharmaceut.4c00942

Microneedles (MNs) offer the potential for discrete and painless transdermal drug delivery, yet poor insertion and dosing consistency have hindered their clinical translation. Specifically, hollow MNs are appropriate for the administration of liquid... Read More about Using Oscillation to Improve the Insertion Depth and Consistency of Hollow Microneedles for Transdermal Insulin Delivery with Mechanistic Insights.

Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy (2024)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mather, M. L., Alsaleem, M., Bateman-Price, T. D., Patke, R., Ball, G., Mongan, N. P., & Rakha, E. (2025). Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy. Journal of Microscopy, 297(2), 135-152. https://doi.org/10.1111/jmi.13361

Breast cancer (BC) is characterised by a high level of heterogeneity, which is influenced by the interaction of neoplastic cells with the tumour microenvironment. The diagnostic and prognostic role of the tumour stroma in BC remains to be defined. Di... Read More about Geometric characteristics of stromal collagen fibres in breast cancer using differential interference contrast microscopy.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., Kariri, Y., Ntekim, A., Robinson, B. D., Khani, F., Gudas, L. J., Allegrucci, C., James, V. H., Madhusudan, S., Mather, M., Emes, R. D., Archer, N., Fray, R. G., Rakha, E., Jeyapalan, J. N., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.