Outputs (55)

Modulation of the biological response to surfaces through the controlled deposition of 3D polymeric surfactants (2025)
Journal Article
Cuzzucoli Crucitti, V., Hajiali, H., Dundas, A. A., Jayawarna, V., Tomolillo, D., Francolini, I., Vuotto, C., Salmeron-Sanchez, M., Dalby, M. J., Alexander, M. R., Wildman, R. D., Rose, F. R. A. J., & Irvine, D. J. (2025). Modulation of the biological response to surfaces through the controlled deposition of 3D polymeric surfactants. Journal of Materials Chemistry B, 13(15), 4657-4670. https://doi.org/10.1039/d4tb01941e

Biomaterials play a crucial role in modern medicine through their use as medical implants and devices. However, they can support biofilm formation and infection, and lack integration with the surrounding human tissue at the implant site. This work re... Read More about Modulation of the biological response to surfaces through the controlled deposition of 3D polymeric surfactants.

Rapid, Highly Sustainable Ring-Opening Polymerization via Resonant Acoustic Mixing (2025)
Journal Article
Fowler, H. R., O’Shea, R., Sefton, J., Howard, S. C., Muir, B. W., Stockman, R. A., Taresco, V., & Irvine, D. J. (2025). Rapid, Highly Sustainable Ring-Opening Polymerization via Resonant Acoustic Mixing. ACS Sustainable Chemistry and Engineering, 13(5), 1916–1926. https://doi.org/10.1021/acssuschemeng.4c06330

Reported herein is the first combination of resonant acoustic mixing (RAM) and controlled ring-opening polymerization (ROP) to deliver fully sustainable, end-functionalized, biodegradable polymers via a manufacturing route with a much-reduced environ... Read More about Rapid, Highly Sustainable Ring-Opening Polymerization via Resonant Acoustic Mixing.

Dielectrically Monitored Flow Synthesis of Functional Vaccine Adjuvant Mixtures via Microwave-Assisted Catalytic Chain Transfer Processing (2025)
Journal Article
Hege, C. S., Hamilton, I. E., Dundas, A. A., Adlington, K., Walker, E., Henke, H., Wang, K., Dimitrakis, G., Buttress, A., Dodds, C., Fox, C. B., & Irvine, D. J. (2025). Dielectrically Monitored Flow Synthesis of Functional Vaccine Adjuvant Mixtures via Microwave-Assisted Catalytic Chain Transfer Processing. Chemistry, 7(1), Article 10. https://doi.org/10.3390/chemistry7010010

A novel flow process to produce low-molecular-weight (Mwt) methacrylate oligomer mixtures that have potential as vaccine adjuvants and chain transfer agents (CTAs) is reported. The chemistry and process were designed to significantly reduce the numbe... Read More about Dielectrically Monitored Flow Synthesis of Functional Vaccine Adjuvant Mixtures via Microwave-Assisted Catalytic Chain Transfer Processing.

Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening (2025)
Presentation / Conference Contribution
Yong, L. X., Zhou, Z., Vallières, C., He, Y., Cuzzucoli Crucitti, V., Alexander, M. R., Avery, S., Wildman, R., & Irvine, D. (2024, August). Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening. Presented at International Conference on Computational & Experimental Engineering and Sciences, Singapore, Singapore

The fungal pathogen Candida albicans (C. albicans) is particularly problematic for immunocompromised patients and those with medical implants. Introducing Candida-resistant medical devices could potentially reduce mortality rates from such infections... Read More about Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening.

Towards a scalable cacao pod husk biorefinery: Understanding the effects of process conditions on phenolic antioxidant extraction and residual solid properties (2024)
Journal Article
Dewi, S. R., Stevens, L. A., Anwar, M., Mao, Y., Ferrari, R. S., Irvine, D. J., & Binner, E. R. (2025). Towards a scalable cacao pod husk biorefinery: Understanding the effects of process conditions on phenolic antioxidant extraction and residual solid properties. Chemical Engineering Science, 305, Article 121171. https://doi.org/10.1016/j.ces.2024.121171

Cacao pod husk (CPH) is a potential source of phenolic-based antioxidants and lignocellulosic compounds. Sample pretreatments and extraction conditions were investigated to understand their effects on extraction yields and implications for industrial... Read More about Towards a scalable cacao pod husk biorefinery: Understanding the effects of process conditions on phenolic antioxidant extraction and residual solid properties.

High resolution 3D printed biocatalytic reactor core with optimized efficiency for continuous flow synthesis (2024)
Journal Article
Attwood, S. J., Leech, D., He, Y., Croft, A., Hague, R. J., Irvine, D. J., Wildman, R. D., & Pordea, A. (2025). High resolution 3D printed biocatalytic reactor core with optimized efficiency for continuous flow synthesis. Chemical Engineering Science, 305, Article 121156. https://doi.org/10.1016/j.ces.2024.121156

3D printing has the potential to transform biocatalytic continuous flow reactor technology, where precise control of topology is essential for maximizing reactor performance. By embedding enzymatic catalysts in polymer hydrogel networks, continuous s... Read More about High resolution 3D printed biocatalytic reactor core with optimized efficiency for continuous flow synthesis.

Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices (2024)
Journal Article
Yong, L. X., Sefton, J., Vallières, C., Rance, G. A., Hill, J., Cuzzucoli Crucitti, V., Dundas, A. A., Rose, F. R., Alexander, M. R., Wildman, R., He, Y., Avery, S. V., & Irvine, D. J. (2024). Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices. ACS Applied Materials and Interfaces, 16(40), 54508–54519. https://doi.org/10.1021/acsami.4c04833

This study reports the development of the first copolymer material that (i) is resistant to fungal attachment and hence biofilm formation, (ii) operates via a nonkilling mechanism, i.e., avoids the use of antifungal actives and the emergence of funga... Read More about Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices.

Understanding Microwave Interactions with Polymers to Enable Advanced Plastic Chemical Recycling (2024)
Journal Article
Adam, M., Hjalmarsson, N., Lee, C. S., Irvine, D. J., Robinson, J., & Binner, E. (2024). Understanding Microwave Interactions with Polymers to Enable Advanced Plastic Chemical Recycling. Polymer Testing, 137, Article 108483. https://doi.org/10.1016/j.polymertesting.2024.108483

The widespread adoption of plastics has led to substantial production and waste generation, raising environmental concerns. Chemical recycling offers a promising solution to enhance recycling rates, with microwave heating emerging as an attractive te... Read More about Understanding Microwave Interactions with Polymers to Enable Advanced Plastic Chemical Recycling.

Simultaneous geraniol and citronellol transesterification using Pseudomonas fluorescens lipase for the production of fragrance and flavour esters: a kinetic study (2024)
Journal Article
Wikaputri, A. S., Irvine, D. J., Stockman, R. A., & Shivaprasad, P. (2024). Simultaneous geraniol and citronellol transesterification using Pseudomonas fluorescens lipase for the production of fragrance and flavour esters: a kinetic study. Journal of Agriculture and Food Research, 16, Article 101186. https://doi.org/10.1016/j.jafr.2024.101186

This study aims to develop, for the very first time, a kinetic model for the simultaneous transesterification of geraniol and citronellol using Pseudomonas fluorescens lipase to produce their respective esters. This allows us to test the feasibility... Read More about Simultaneous geraniol and citronellol transesterification using Pseudomonas fluorescens lipase for the production of fragrance and flavour esters: a kinetic study.

Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study (2024)
Journal Article
Kalenderski, K., Dubern, J.-F., Lewis-Lloyd, C., Jeffery, N., Heeb, S., Irvine, D. J., Sloan, T. J., Birch, B., Andrich, D., Humes, D., Alexander, M. R., & Williams, P. (2024). Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study. Journal of Urology Open PLus, 2(1), Article e00005. https://doi.org/10.1097/JU9.0000000000000097

Purpose: Biofilm formation and biomineralization on urinary catheters may cause severe complications including infection and obstruction. Here, we describe an in vitro evaluation and prospective pilot clinical study of a silicone catheter coated with... Read More about Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study.