Outputs (3)

Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects (2023)
Journal Article
Diringer, M., Coliat, P., Mathieu, C., Laurent, N., Mura, C., Banerjee, M., Zhu, C., Grabowska, A., Ritchie, A., Clarke, P., Bernard, A., Vit, C., Burckel, H., Noel, G., Harvey, P., Pivot, X., & Detappe, A. (2023). Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects. Small, 19(12), Article 2205961. https://doi.org/10.1002/smll.202205961

Improving the tumor reoxygenation to sensitize the tumor to radiation therapy is a cornerstone in radiation oncology. Here, the pre‐clinical development of a clinically transferable liposomal formulation encapsulating trans sodium crocetinate (NP TSC... Read More about Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.

Metal-based imaging agents: progress towards interrogating neurodegenerative disease (2020)
Journal Article
Sedgwick, A. C., Brewster, J. T., Harvey, P., Iovan, D. A., Smith, G., He, X.-P., Tian, H., Sessler, J. L., & James, T. D. (2020). Metal-based imaging agents: progress towards interrogating neurodegenerative disease. Chemical Society Reviews, 2020(10), 2886-2915. https://doi.org/10.1039/c8cs00986d

Central nervous system (CNS) neurodegeneration is defined by a complex series of pathological processes that ultimately lead to death. The precise etiology of these disorders remains unknown. Recent efforts show that a mechanistic understanding of th... Read More about Metal-based imaging agents: progress towards interrogating neurodegenerative disease.

Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease (2020)
Journal Article
Brewster II, J. T., Thiabaud, G. D., Harvey, P., Zafar, H., Reuther, J. F., Dell'Acqua, S., Johnson, R. M., Root, H. D., Metola, P., Jasanoff, A., Casella, L., & Sessler, J. L. (2020). Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease. Chem, 6(3), 703-724. https://doi.org/10.1016/j.chempr.2019.12.016

The complex etiology of neurodegeneration continues to stifle efforts to develop effective therapeutics. New agents elucidating key pathways causing neurodegeneration might serve to increase our understanding and potentially lead to improved treatmen... Read More about Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease.