Outputs (22)

The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model (2014)
Journal Article
Chernyavsky, I. L., Croisier, H., Chapman, L. A., Kimpton, L. S., Hiorns, J. E., Brook, B., Jensen, O. E., Billington, C. K., Hall, I. P., & Johnson, S. R. (2014). The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model. PLoS ONE, 9(3), Article e90162. https://doi.org/10.1371/journal.pone.0090162

Despite a large amount of in vitro data, the dynamics of airway smooth muscle (ASM) mass increase in the airways of patients with asthma is not well understood. Here, we present a novel mathematical model that describes qualitatively the growth dynam... Read More about The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model.

Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model (2013)
Journal Article
Croisier, H., Tan, X., Perez-Zoghbi, J. F., Sanderson, M. J., Sneyd, J., & Brook, B. S. (2013). Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model. PLoS ONE, 8(7), Article e69598. https://doi.org/10.1371/journal.pone.0069598

Intracellular dynamics of airway smooth muscle cells (ASMC) mediate ASMC contraction and proliferation, and thus play a key role in airway hyper-responsiveness (AHR) and remodelling in asthma. We evaluate the importance of store-operated entry (SOC... Read More about Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.