Outputs (48)

‘Vivaldi’: an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2 (2025)
Journal Article
McClure, P. C., Tsoleridis, T., Hill, J. D., Holmes, N., Chappell, J. G., Byaruhanga, T., Duncan, J., Tofan, M., Berry, L., Clark, G., L. Irving, W., Tarr, A. W., Ball, J. K., Astbury, S., & Loose, M. (2025). ‘Vivaldi’: an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2. Microbial Genomics, 11, Article 001451. https://doi.org/10.1099/mgen.0.001451

Prior to the emergence of SARS-CoV-2 in 2019, alphacoronaviruses 229E and NL63 and betacoronaviruses OC43 and HKU1 were already established endemic ‘common cold’ viral infections. Despite their collective contribution towards global respiratory morbi... Read More about ‘Vivaldi’: an amplicon-based whole-genome sequencing method for the four seasonal human coronaviruses, 229E, NL63, OC43 and HKU1, alongside SARS-CoV-2.

Practical Crystallography with a Transmission Electron Microscope (2025)
Preprint / Working Paper
Weare, B. L., Fung, K. L. Y., Cardillo-Zallo, I., Cull, W. J., Fay, M. W., Argent, S. P., & Brown, P. D. Practical Crystallography with a Transmission Electron Microscope

Three-dimensional electron diffraction (3DED) is a powerful technique providing for crystal structure solutions of sub-micron sized crystals too small for structure determination via X-ray techniques. The entry requirement, however, of a transmission... Read More about Practical Crystallography with a Transmission Electron Microscope.

Genome Mining Reveals a Novel Nephthenol‐Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis (2025)
Journal Article
Ducker, C., McKeown, C., Da Silva, I. F. P., Souza, I. T., Pickett, J. A., Santana, A. E. G., & Oldham, N. J. (2025). Genome Mining Reveals a Novel Nephthenol‐Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis. ChemBioChem, https://doi.org/10.1002/cbic.202500292

Populations of the sandfly, Lutzomyia longipalpis, use the diterpene sobralene as a sex/aggregation pheromone, which is likely produced in the insect through the activity of a recently discovered noncanonical terpene synthase (TPS). This study shows... Read More about Genome Mining Reveals a Novel Nephthenol‐Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis.

Stereoselective deprotonation installs an unusual Z-8,9 double bond during biosynthesis of the diterpene pheromone sobralene (2025)
Journal Article
Da Silva, I. F. P., Ducker, C., Pickett, J. A., Santana, A. E. G., & Oldham, N. J. (2025). Stereoselective deprotonation installs an unusual Z-8,9 double bond during biosynthesis of the diterpene pheromone sobralene. Chemical Communications, https://doi.org/10.1039/d5cc03298a

A terpene synthase from the sandfly Lutzomyia longipalpis, catalyses stereoselective removal of the pro-S proton from C8 of geranylgeranyl diphosphate to generate the characteristic (Z)-8,9 double bond seen in the diterpene pheromone sobralene. Reten... Read More about Stereoselective deprotonation installs an unusual Z-8,9 double bond during biosynthesis of the diterpene pheromone sobralene.

Polyglycerol Resin Towards Sustainable 3D-Printing (2025)
Journal Article
George, K., Krumins, E., Tan, E., He, Y., Wildman, R. D., Owen, R., Segal, J., Cuzzucoli Crucitti, V., & Taresco, V. (2025). Polyglycerol Resin Towards Sustainable 3D-Printing. Faraday Discussions, https://doi.org/10.1039/d5fd00043b

Additive manufacturing (AM) techniques, also named as three-dimensional 3D-printing, have been widely recognised as promising technologies for rapid production of novel, personalised drug-delivery systems, scaffolds for biofabrication, food applicati... Read More about Polyglycerol Resin Towards Sustainable 3D-Printing.

Atomic-Scale Imaging of Transformation of Nickel Nanocrystals to Nickel Carbides in Real Time (2025)
Journal Article
Yan, P., Zhang, D., Zhang, W., Sun, K., Jin, M., Chamberlain, T., Khlobystov, A. N., Kaiser, U., Hu, Y., & Cao, K. (2025). Atomic-Scale Imaging of Transformation of Nickel Nanocrystals to Nickel Carbides in Real Time. ACS Nano, 19(25), 23306-23314. https://doi.org/10.1021/acsnano.5c06292

Transition of metal-to-metal carbide plays a key role in heterogeneous catalysis. We confined nickel nanocrystals in single-walled carbon nanotubes, stimulated delivery of carbon atoms by the 80 keV electron beam, and imaged the entire carbonization... Read More about Atomic-Scale Imaging of Transformation of Nickel Nanocrystals to Nickel Carbides in Real Time.

Enhancing Monte Carlo Tree Search for Retrosynthesis (2025)
Journal Article
Blackshaw, T. M., Davies, J. C., Spoerer, K. T., & Hirst, J. D. (in press). Enhancing Monte Carlo Tree Search for Retrosynthesis. Journal of Chemical Information and Modeling, https://doi.org/10.1021/acs.jcim.5c00417

Computer-Assisted Synthesis Programs are increasingly employed by organic chemists. Often, these tools combine neural networks for policy prediction with heuristic search algorithms. We propose two novel enhancements, which we call eUCT and dUCT, to... Read More about Enhancing Monte Carlo Tree Search for Retrosynthesis.

Benchmarking TERS and TEPL probes: towards a reference sample for quantification of near-field enhancement factors in gap and non-gap modes (2025)
Journal Article
Kerfoot, J., Legge, E. J., Collins, A., Chauhan, J., Rossnagel, K., Beton, P. H., Mellor, C. J., Pollard, A. J., Rance, G. A., & George, M. W. (2025). Benchmarking TERS and TEPL probes: towards a reference sample for quantification of near-field enhancement factors in gap and non-gap modes. Analyst, https://doi.org/10.1039/D5AN00456J

Benchmarking the near-field signal enhancement attained using plasmonic metal-coated atomic force microscopy (AFM) probes for tip-enhanced Raman spectroscopy (TERS) and tip-enhanced photoluminescence (TEPL) measurements is challenging given the absen... Read More about Benchmarking TERS and TEPL probes: towards a reference sample for quantification of near-field enhancement factors in gap and non-gap modes.

Harnessing enzymes for greener polymerisations: advances in chain and step growth processes (2025)
Journal Article
Dixon, E. G., Ciano, L., Pordea, A., Alvey, K., & Taresco, V. (2025). Harnessing enzymes for greener polymerisations: advances in chain and step growth processes. Polymer Chemistry, https://doi.org/10.1039/d5py00223k

Synthetic organic polymers face increasing scrutiny due to their environmental impact, as most industrial monomers are petrol-based. Key concerns include fossil fuel consumption, greenhouse gas emissions, reliance on non-renewable feedstocks, insuffi... Read More about Harnessing enzymes for greener polymerisations: advances in chain and step growth processes.

Inter- and Intramolecular On-Surface Synthesis of Porphyrin-Based Nanostructures on Au(111) and Cu(111) (2025)
Journal Article
Frampton, E. S., Clarke, M., Edmondson, M., Gray, A., Bradford, J., Warwick, L., Pearce, N., Champness, N. R., & Saywell, A. (2025). Inter- and Intramolecular On-Surface Synthesis of Porphyrin-Based Nanostructures on Au(111) and Cu(111). ACS Applied Nano Materials, 8(24), 12608-12618. https://doi.org/10.1021/acsanm.5c01525

Surface-confined synthesis provides alternative reaction pathways to those utilized within solution-phase chemistry and offers a route to extended molecular architectures with nanoscale dimensions and fascinating magnetic, electronic, and catalytic p... Read More about Inter- and Intramolecular On-Surface Synthesis of Porphyrin-Based Nanostructures on Au(111) and Cu(111).