Outputs (5)

Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization (2017)
Journal Article
O’Duill, M. L., Matsuura, R., Wang, Y., Turnbull, J. L., Gurak, J. A., Gao, D.-W., Lu, G., Liu, P., & Engle, K. M. (2017). Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization. Journal of the American Chemical Society, 139(44), 15576-15579. https://doi.org/10.1021/jacs.7b08383

Removable tridentate directing groups inspired by pincer ligands have been designed to stabilize otherwise kinetically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates. This family of directing groups enables regioselectiv... Read More about Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization.

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides (2017)
Journal Article
Wood, A. J. L., Weise, N. J., Frampton, J. D., Dunstan, M. S., Hollas, M. A., Derrington, S. R., Lloyd, R. C., Quaglia, D., Parmeggiani, F., Leys, D., Turner, N. J., & Flitsch, S. L. (2017). Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides. Angewandte Chemie, 56(46), 14498-14501. https://doi.org/10.1002/anie.201707918

Photoinduced Hydrogen Fuel Production and Water Decontamination Technologies. Orthogonal Strategies with a Parallel Future? (2017)
Journal Article
Lanterna, A. E., & Scaiano, J. C. (2017). Photoinduced Hydrogen Fuel Production and Water Decontamination Technologies. Orthogonal Strategies with a Parallel Future?. ACS Energy Letters, 2(8), 1909-1910. https://doi.org/10.1021/acsenergylett.7b00641

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis (2017)
Journal Article
Gahloth, D., Dunstan, M. S., Quaglia, D., Klumbys, E., Lockhart-Cairns, M. P., Hill, A. M., Derrington, S. R., Scrutton, N. S., Turner, N. J., & Leys, D. (2017). Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis. Nature Chemical Biology, 13(9), 975-981. https://doi.org/10.1038/nchembio.2434

Carboxylic acid reductase (CAR) catalyzes the ATP- and NADPH-dependent reduction of carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal peptide synthetases, consisting of an adenylation domain fused via a peptid... Read More about Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.

Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl (2017)
Journal Article
Derosa, J., Cantu, A. L., Boulous, M. N., O’Duill, M. L., Turnbull, J. L., Liu, Z., De La Torre, D. M., & Engle, K. M. (2017). Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl. Journal of the American Chemical Society, 139(14), 5183-5193. https://doi.org/10.1021/jacs.7b00892

A regioselective anti-hydrochlorination of unactivated alkynes is reported. The reaction utilizes in situ generated HCl as the source of both the Cl - and H + and is catalyzed by palladium(II) acetate, with loadings as low as 25 ppm. Removable picoli... Read More about Palladium(II)-Catalyzed Directed anti-Hydrochlorination of Unactivated Alkynes with HCl.