Outputs (139)

Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation (2016)
Journal Article
Zhou, C.-X., Zhu, X.-Q., Elsheikha, H. M., He, S., Li, Q., Zhou, D.-H., & Suo, X. (2016). Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation. Journal of Proteomics, 148, 12-19. https://doi.org/10.1016/j.jprot.2016.07.010

Toxoplasma gondii is a medically and economically important protozoan parasite. However, the molecular mechanisms of its sporulation remain largely unknown. Here, we applied iTRAQ coupled with 2D LC–MS/MS proteomic analysis to investigate the proteom... Read More about Global iTRAQ-based proteomic profiling of Toxoplasma gondii oocysts during sporulation.

Updates on feline aelurostrongylosis and research priorities for the next decade (2016)
Journal Article
Elsheikha, H. M., Schnyder, M., Traversa, D., Di Cesare, A., Wright, I., & Lacher, D. W. (2016). Updates on feline aelurostrongylosis and research priorities for the next decade. Parasites and Vectors, 9, Article 389. https://doi.org/10.1186/s13071-016-1671-6

Feline aelurostrongylosis, caused by the metastrongyloid nematode Aelurostrongylus abstrusus, is an important gastropod-borne parasitic lung disease in cats. Infection with A. abstrusus is widespread globally, but the increasing awareness of this par... Read More about Updates on feline aelurostrongylosis and research priorities for the next decade.

Using combined diagnostic test results to hindcast trends of infection from cross-sectional data (2016)
Journal Article
Rydevik, G., Innocent, G. T., Marion, G., Davidson, R. S., White, P. C., Billinis, C., …Hutchings, M. R. (2016). Using combined diagnostic test results to hindcast trends of infection from cross-sectional data. PLoS Computational Biology, 12(7), 1-19. https://doi.org/10.1371/journal.pcbi.1004901

Infectious disease surveillance is key to limiting the consequences from infectious pathogens and maintaining animal and public health. Following the detection of a disease outbreak, a response in proportion to the severity of the outbreak is require... Read More about Using combined diagnostic test results to hindcast trends of infection from cross-sectional data.

Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity (2016)
Journal Article
Xu, G., Zhang, X., Gao, W., Wang, C., Wang, J., Sun, H., …Pu, J. (in press). Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity. Journal of Virology, 90(18), https://doi.org/10.1128/JVI.00883-16

Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that PA mutation K356R (PA-K356R) has become predominant since 2014 in avian H9N2 viruses in... Read More about Prevailing PA mutation K356R in avian influenza H9N2 virus increases mammalian replication and pathogenicity.

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth (2016)
Journal Article
Brown, D. M., Williams, H., Ryan, K., Wilson, T., Daniel, Z. C., Mareko, M. H. D., …Parr, T. (2016). Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Scientific Reports, 6(1), https://doi.org/10.1038/srep28693

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombi... Read More about Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth.

Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration (2016)
Journal Article
Cai, H., Pollard, A. K., Craig, E. L., & Chakrabarti, L. (in press). Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration. PLoS ONE, 11(6), Article e0157405. https://doi.org/10.1371/journal.pone.0157405

Mitochondrial function, in particular complex 1 of the electron transport chain (ETC), has been shown to decrease during normal ageing and in neurodegenerative disease. However, there is some debate concerning which area of the brain has the greatest... Read More about Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration.

Associations between sheep farmer attitudes, beliefs, emotions and personality, and their barriers to uptake of best practice: the example of footrot (2016)
Journal Article
O’Kane, H., Ferguson, E., Kaler, J., & Green, L. (2017). Associations between sheep farmer attitudes, beliefs, emotions and personality, and their barriers to uptake of best practice: the example of footrot. Preventive Veterinary Medicine, 139, 123-133. https://doi.org/10.1016/j.prevetmed.2016.05.009

There is interest in understanding how farmers’ behaviour influences their management of livestock. We extend the theory of planned behaviour with farmers attitudes, beliefs, emotions and personality to investigate how these are associated with manag... Read More about Associations between sheep farmer attitudes, beliefs, emotions and personality, and their barriers to uptake of best practice: the example of footrot.

STAT5 induces miR-21 expression in cutaneous T cell lymphoma (2016)
Journal Article
Lindahl, L. M., Fredholm, S., Joseph, C., Nielsen, B. S., Jønson, L., Willerslev-Olsen, A., …Odum, N. (2016). STAT5 induces miR-21 expression in cutaneous T cell lymphoma. Oncotarget, https://doi.org/10.18632/oncotarget.10160

In cutaneous T cell lymphomas (CTCL), miR-21 is aberrantly expressed in skin and peripheral blood and displays anti-apoptotic properties in malignant T cells. It is, however, unclear exactly which cells express miR-21 and what mechanisms regulate miR... Read More about STAT5 induces miR-21 expression in cutaneous T cell lymphoma.

Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle (2016)
Journal Article
Swift, B. M., Huxley, J., Plain, K. M., Begg, D. J., de Silva, K., Purdie, A. C., …Rees, C. (2016). Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle. BMC Veterinary Research, 12, Article 115. https://doi.org/10.1186/s12917-016-0728-2

Background Disseminated infection and bacteraemia is an underreported and under-researched aspect of Johne’s disease. This is mainly due to the time it takes for Mycobacterium avium subsp. paratuberculosis (MAP) to grow and lack of sensitivity of... Read More about Evaluation of the limitations and methods to improve rapid phage-based detection of viable Mycobacterium avium subsp. paratuberculosis in the blood of experimentally infected cattle.

Factors associated with the presence and prevalence of contagious ovine digital dermatitis: a 2013 study of 1136 random English sheep flocks (2016)
Journal Article
Dickins, A., Clark, C. C., Kaler, J., Ferguson, E., O’Kane, H., & Green, L. E. (2016). Factors associated with the presence and prevalence of contagious ovine digital dermatitis: a 2013 study of 1136 random English sheep flocks. Preventive Veterinary Medicine, 130, https://doi.org/10.1016/j.prevetmed.2016.06.009

In 2013, a questionnaire was used to gather data on risks for introduction, and factors associated with prevalence, of contagious ovine digital dermatitis (CODD). There were 1136 (28.4%) usable responses from 4000 randomly selected sheep farmers in E... Read More about Factors associated with the presence and prevalence of contagious ovine digital dermatitis: a 2013 study of 1136 random English sheep flocks.