Outputs (117)

iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine (2020)
Journal Article
He, J., Ma, J., Wang, J., Zhang, F., Li, J., Zhai, B., …Zhu, X. (2020). iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine. Microorganisms, 8(4), Article 518. https://doi.org/10.3390/microorganisms8040518

Toxoplasma gondii is a leading cause of foodborne illness and consumption of undercooked pig meat is a major risk factor for acquiring toxoplasmosis, which causes a substantial burden on society. Here, we used isobaric tags for relative and absolute... Read More about iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine.

Significant transcriptional changes in mature daughter Varroa destructor mites during infestation of different developmental stages of honeybees (2020)
Journal Article
Tu, Y., Wu, J., Elsheikha, H. M., Getachew, A., Zhou, C., Zhou, H., & Xu, S. (2020). Significant transcriptional changes in mature daughter Varroa destructor mites during infestation of different developmental stages of honeybees. Pest Management Science, 76(8), 2736-2745. https://doi.org/10.1002/ps.5821

Background: Varroa destructor is considered a major cause of honeybee (Apis mellifera) colony losses worldwide. Although V. destructor mites exhibit preference behavior for certain honeybee lifecycle stages, the mechanism underlying host finding and... Read More about Significant transcriptional changes in mature daughter Varroa destructor mites during infestation of different developmental stages of honeybees.

RHΔgra17Δnpt1 strain of Toxoplasma gondii elicits protective immunity against acute, chronic and congenital toxoplasmosis in mice (2020)
Journal Article
Sun, L., Liang, Q., Elsheikha, H. M., Cao, X., Nie, L., Li, T., …Wang, J. (2020). RHΔgra17Δnpt1 strain of Toxoplasma gondii elicits protective immunity against acute, chronic and congenital toxoplasmosis in mice. Microorganisms, 8(3), Article 352. https://doi.org/10.3390/microorganisms8030352

In the present study, a dense granule protein 17 (gra17) and novel putative transporter (npt1) double deletion mutant of Toxoplasma gondii RH strain was engineered. The protective efficacy of vaccination using RHΔgra17Δnpt1 tachyzoites against acute,... Read More about RHΔgra17Δnpt1 strain of Toxoplasma gondii elicits protective immunity against acute, chronic and congenital toxoplasmosis in mice.

Transcriptional changes in Toxoplasma gondii in response to treatment with monensin (2020)
Journal Article
Zhai, B., He, J., Elsheikha, H. M., Li, J., Zhu, X., & Yang, X. (2020). Transcriptional changes in Toxoplasma gondii in response to treatment with monensin. Parasites and Vectors, 13, Article 84. https://doi.org/10.1186/s13071-020-3970-1

Background: Infection with the apicomplexan protozoan parasite T. gondii can cause severe and potentially fatal cerebral and ocular disease, especially in immunocompromised individuals. The anticoccidial ionophore drug monensin has been shown to have... Read More about Transcriptional changes in Toxoplasma gondii in response to treatment with monensin.

Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice (2020)
Journal Article
Wang, J., Liang, Q., Li, T., He, J., Bai, M., Cao, X., …Zhu, X. (2020). Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice. Journal of Immunology, 204(6), 1562-1570. https://doi.org/10.4049/jimmunol.1900410

In this study, we generated a tkl1 deletion mutant in the Toxoplasma gondii type 1 RH (RHΔtkl1) strain and tested the protective efficacies of vaccination using RHΔtkl1 tachyzoites against acute, chronic, and congenital T. gondii infections in Kunmin... Read More about Toxoplasma gondii tkl1 Deletion Mutant Is a Promising Vaccine against Acute, Chronic, and Congenital Toxoplasmosis in Mice.

Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection (2020)
Journal Article
Cao, X., Wang, J.-L., Bai, M.-J., Elsheikha, H. M., Liang, Q.-L., Li, T.-L., & Zhu, X.-Q. (2020). Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection. FASEB Journal, 34(2), 3165-3178. https://doi.org/10.1096/fj.201901416rr

Antioxidant enzymes as biomarkers of Cu and Pb exposure in the ground spiders Lycosa terrestris and Pardosa birmanica (2019)
Journal Article
Elsheikha, H. M., Aziz, N., & Butt, A. (2020). Antioxidant enzymes as biomarkers of Cu and Pb exposure in the ground spiders Lycosa terrestris and Pardosa birmanica. Ecotoxicology and Environmental Safety, 190, Article 110054. https://doi.org/10.1016/j.ecoenv.2019.110054

© 2019 Elsevier Inc. Heavy metal exposure induces oxidative stress in terrestrial organisms, which they counteract via activation of antioxidant biomarkers. The present study investigated the effects of copper (Cu) and lead (Pb) on the total antioxid... Read More about Antioxidant enzymes as biomarkers of Cu and Pb exposure in the ground spiders Lycosa terrestris and Pardosa birmanica.

Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes (2019)
Journal Article
Aziz, N., Butt, A., & Elsheikha, H. M. (2020). Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes. Environmental Science and Pollution Research, 27, 3309–3319. https://doi.org/10.1007/s11356-019-07055-0

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Major concerns exist regarding the environmental and human health risks caused by exposure to heavy metals. Spiders are often used as a model in ecotoxicological studies to assess soil po... Read More about Assessment of bioaccumulation of cu and Pb in experimentally exposed spiders, Lycosa terrestris and Pardosa birmanica, using different exposure routes.

Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii (2019)
Journal Article
Cao, X., Wang, J., Elsheikha, H. M., Li, T., Sun, L., Liang, Q., …Lin, R. (2019). Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology, 9, Article 418. https://doi.org/10.3389/fcimb.2019.00418

In this study, we characterized the role of amylo-alpha-1,6-glucosidase (Aa16GL) in the biology and infectivity of Toxoplasma gondii, using Aa16GL-deficient parasites of type I RH and type II Prugniaud (Pru) strains. The subcellular localization of A... Read More about Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii.

Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China (2019)
Journal Article
Cong, W., Zhang, N.-Z., Hu, R.-S., Zou, F.-C., Zou, Y., Zhong, W.-Y., …Elsheikha, H. M. (2020). Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China. Ecotoxicology and Environmental Safety, 189, Article 109999. https://doi.org/10.1016/j.ecoenv.2019.109999

Copyright © 2019 Elsevier Inc. All rights reserved. In the present study, we performed a cross-sectional survey to determine the occurrence and genotype distribution of T. gondii DNA in soil samples collected from different sources from six geographi... Read More about Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in China.