Outputs (91)

The characteristics and prognostic significance of histone H1 expression in breast cancer (2024)
Journal Article
Lashen, A. G., Almalki, N., Toss, M., Mirza, S., Malki, M. I., Rutland, C. S., Jeyapalan, J. N., Green, A. R., Mongan, N. P., Madhusudan, S., & Rakha, E. A. (2024). The characteristics and prognostic significance of histone H1 expression in breast cancer. Pathology, https://doi.org/10.1016/j.pathol.2024.03.012

Histone H1 (H.H1) is involved in chromatin organisation and gene regulation and is overexpressed in many malignant tumours, including breast cancer (BC). This study proposed and evaluated the prognostic role of H.H1 expression in BC. H.H1 mRNA exp... Read More about The characteristics and prognostic significance of histone H1 expression in breast cancer.

Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis (2024)
Journal Article
Alsafy, M. A. M., El-Gendy, S. A. A., Atkinson, B., Sturrock, C. J., Kamal, B. M., Alibhai, A., …Rutland, C. S. (2024). Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis. Microscopy and Microanalysis, 30(3), 574-593. https://doi.org/10.1093/mam/ozae046

Ossa cordis, bones located within the heart trigones, are often classified as heterotopic or ectopic bones. Despite their high prevalence in cattle and some other bovids, little is known about their structure or development. Scanning electron microsc... Read More about Novel Insights Into the Architecture of Macro and Microstructures in Cattle Ossa Cordis.

Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma (2024)
Journal Article
de Brot, S., Cobb, J., Alibhai, A. A., Jackson-Oxley, J., Haque, M., Patke, R., …Rutland, C. S. (2024). Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma. Cancers, 16(10), Article 1945. https://doi.org/10.3390/cancers16101945

Osteosarcoma (OSA) is the most common type of primary bone malignancy in people and dogs. Our previous molecular comparisons of canine OSA against healthy bone resulted in the identification of differentially expressed protein-expressing genes (forkh... Read More about Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., …James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.

Changes in Immune Response during Pig Gestation with a Focus on Cytokines (2024)
Journal Article
Velez, C., Williamson, D., Lorena Cánovas, M., Romina Giai, L., Rutland, C., Pérez, W., & Barbeito, C. G. (2024). Changes in Immune Response during Pig Gestation with a Focus on Cytokines. Veterinary Sciences, 11(1), Article 50. https://doi.org/10.3390/vetsci11010050

Pigs have the highest percentage of embryonic death not associated with specific diseases of all livestock species, at 20–45%. During gestation processes, a series of complex alterations can arise, including embryonic migration and elongation, matern... Read More about Changes in Immune Response during Pig Gestation with a Focus on Cytokines.

Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression (2023)
Journal Article
Atallah, N. M., Haque, M., Quinn, C., Toss, M. S., Makhlouf, S., Ibrahim, A., …Rakha, E. (2023). Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. European Journal of Cancer, 195, Article 113371. https://doi.org/10.1016/j.ejca.2023.113371

Background: Breast cancer (BC) expressing low levels of human epidermal growth factor receptor 2 (HER2 Low) is an emerging category that needs further refining. This study aims to provide a comprehensive clinico-pathological and molecular profile of... Read More about Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression.

Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish (2023)
Journal Article
Emeish, W. F. A., Fawaz, M. M., Hussein, N. M., Al-Amgad, Z., Abd-ElHafeez, H. H., Rutland, C. S., & Bakry, K. A. (2023). Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish. Microscopy and Microanalysis, 29(5), 1774-1790. https://doi.org/10.1093/micmic/ozad091

Henneguya species are myxozoans, a suborder of Cnidaria, which can affect the gills and extrarespiratory organs of the African sharptooth catfish, Clarias gariepinus. This research describes natural infection-induced histological alterations caused b... Read More about Characterizing Two New Henneguya Species in the Respiratory Organs of African Sharptooth Catfish.

Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry (2023)
Journal Article
Alsafy, M. A., El-Gendy, S. A., Kamal, B. M., Rutland, C. S., Abd-Elhafeez, H. H., Soliman, S., …Nomir, A. G. (2023). Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry. BMC Zoology, 8, Article 12. https://doi.org/10.1186/s40850-023-00173-w

Dromedary camel heart morphology is a crucial research topic with clinical applications. The study aims to understand the dromedary camel anatomy, morphology, and architecture of the ventricular mass. Results: Sagittal and transverse gross sections w... Read More about Heart ventricles of the dromedary camel (Camelus dromedarius): new insights from sectional anatomy, 3D computed tomography, and morphometry.

Cardiovascular Stem Cell Applications in Experimental Animal Models (2023)
Book Chapter
Jeyapalan, J. N., Cockcroft, J., Rizvanov, A. A., Haider, K. H., & Rutland, C. S. (2023). Cardiovascular Stem Cell Applications in Experimental Animal Models. In K. H. Haider (Ed.), Cardiovascular Applications of Stem Cells (465-490). Springer Nature Singapore. https://doi.org/10.1007/978-981-99-0722-9_16

Stem cells are increasingly used in various species for differing diseases, most frequently experimentally. In addition, several animals are also used as models for both veterinary and human medicine. Differing stem cell types have been trialed with... Read More about Cardiovascular Stem Cell Applications in Experimental Animal Models.

Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758) (2023)
Journal Article
El-Bakary, N. E., Alsafy, M. A., Rutland, C. S., El-Gendy, S. A., & Kamal, B. M. (2023). Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758). Anatomia, Histologia, Embryologia, 52(6), 821-1033. https://doi.org/10.1111/ahe.12943

Trichiurus lepturus is a carnivorous fish, and most of the previous anatomical research has focused on computed tomography imaging and histology of their teeth and fangs, while the remaining structures of pharyngeal cavity remain unexplored. The pres... Read More about Anatomical oropharyngeal cavity specialisations in the cutlassfish (Trichiurus lepturus, Linnaeus, 1758).