Outputs (15)

Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: a retrospective analysis of the EUSOMA database (2025)
Journal Article
Catanuto, G., Gentile, D., Martorana, F., Tomatis, M., Ponti, A., Marotti, L., Aristei, C., Cardoso, M. J., Cheung, K. L., Curigliano, G., De Vries, J., Karakatsanis, A., Santini, D., Sardanelli, F., Van Dam, P., Rubio, I. T., & EUSOMA Working Group. (2025). Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: a retrospective analysis of the EUSOMA database. EJSO - European Journal of Surgical Oncology, 51(6), Article 109643. https://doi.org/10.1016/j.ejso.2025.109643

Aims: We investigated factors related to the type of surgery, i.e. mastectomy versus breast conserving surgery (BCS), in breast cancer (BC) patients with complete pathologic response in the breast (ypT0) after neoadjuvant therapy (NAT). Methods: A re... Read More about Clinico-pathological features predicting indication to mastectomy in breast cancer patients achieving complete response after neoadjuvant therapy: a retrospective analysis of the EUSOMA database.

Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women (2025)
Journal Article
Parks, R. M., & Cheung, K.-L. (2025). Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women. Cancers, 17(3), Article 346. https://doi.org/10.3390/cancers17030346

The global population is ageing and the risk of breast cancer increases with age. Therefore, we can expect an increase in the number of cases of breast cancer worldwide in the next 20 years. Currently, there are few age-specific guidelines for the ma... Read More about Updates and Future Directions for the Nottingham Research Programme on Primary Breast Cancer in Older Women.

Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model (2024)
Journal Article
Francis, J., Baxter, M., Giza, D., Cheung, K.-L., & Parks, R. (2024). Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model. Drugs and Aging, 42(1), 1-7. https://doi.org/10.1007/s40266-024-01167-0

Breast cancer remains the most prevalent cancer worldwide, necessitating advancements in its management. Surgery remains the recommended primary treatment although neoadjuvant or adjuvant treatments, such as chemotherapy, may also be indicated. Howev... Read More about Patient-Reported Outcomes in Geriatric Oncology—Balancing Quality of Life and Therapeutic Effectiveness Using Primary Breast Cancer as a Model.

The care of older patients with cancer across the United Kingdom in 2024: A narrative review by the International Society of Geriatric Oncology UK Country Group (2024)
Journal Article
Gomes, F., Farrington, N., Pearce, J., Swinson, D., Welford, J., Greystoke, A., Baxter, M., Brown-Kerr, A. G., Wyld, L., Morgan, J., Battisti, N. M. L., Barrell, A., Cobben, D., Cree, A., Johnston, M., Colquhoun, K., Phillips, I., Smith, J., Stapley, S., Lyons, L., …Cheung, K.-L. (2025). The care of older patients with cancer across the United Kingdom in 2024: A narrative review by the International Society of Geriatric Oncology UK Country Group. Journal of Geriatric Oncology, 16(1), Article 102133. https://doi.org/10.1016/j.jgo.2024.102133

The worldwide population is ageing, alongside an increase in cancer incidence rates. Over the past 10 years, there has been huge progress in the field of oncology with earlier diagnosis and an expansion of treatment options, leading to a growing numb... Read More about The care of older patients with cancer across the United Kingdom in 2024: A narrative review by the International Society of Geriatric Oncology UK Country Group.

Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET) (2024)
Journal Article
Hubbard, T., Wright, G., Morgan, J., Martin, C., Walters, S., Cheung, K.-L., Audisio, R., Reed, M., & Wyld, L. (2024). Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET). Breast, 77, Article 103768. https://doi.org/10.1016/j.breast.2024.103768

Background: This study reports the detailed management and outcomes of women treated with Primary Endocrine Therapy (PET) in a large prospective UK cohort of older women (≥70) with breast cancer. Methods: This was an unplanned secondary analysis of a... Read More about Management and outcomes for older women with early breast cancer treated with primary endocrine therapy (PET).

Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives (2024)
Journal Article
Mizutani, T., Cheung, K.-L., Hakobyan, Y., Lane, H., Decoster, L., Karnakis, T., Puts, M., Calderon, O., Jørgensen, T. L., Boulahssass, R., Wedding, U., Karampeazis, A., Chan, W. W. L., Banerjee, J., Falci, C., van Leeuwen, B. L., Fonseca, V., Gironés Sarrió, R., Vetter, M., Dougoud, V., …Kanesvaran, R. (2024). Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives. Journal of Geriatric Oncology, 15(2), Article 10179. https://doi.org/10.1016/j.jgo.2024.101709

Introduction
The Sustainable Development Goals of the United Nations include a commitment to “leave no one behind” as a universal goal. To achieve this in geriatric oncology (GO) worldwide, it is important to understand the current state of GO at an... Read More about Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives.

Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels (2024)
Journal Article
Wang, Y., Steinke, D., Gavan, S. P., Chen, T.-C., Carr, M. J., Ashcroft, D. M., Cheung, K.-L., & Chen, L.-C. (2024). Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels. Cancers, 16(4), Article 749. https://doi.org/10.3390/cancers16040749

Primary endocrine therapy (PET) offers non-surgical treatment for older women with early-stage breast cancer who are unsuitable for surgery due to frailty or comorbidity. This research assessed all-cause and breast cancer-specific mortality of PET vs... Read More about Survival Outcomes in Older Women with Oestrogen-Receptor-Positive Early-Stage Breast Cancer: Primary Endocrine Therapy vs. Surgery by Comorbidity and Frailty Levels.

Factors influencing older women's decision‐making related to treatment of operable breast cancer: A qualitative systematic review (2024)
Journal Article
Malcolm, F. L., Howard, P., Klukowska, A. M., Minhas, N., Parks, R. M., & Cheung, K. L. (2024). Factors influencing older women's decision‐making related to treatment of operable breast cancer: A qualitative systematic review. Psycho-Oncology, 33(1), Article e6294. https://doi.org/10.1002/pon.6294

Objective: There is variation in practice in the treatment of older women with breast cancer. International guidelines highlight the importance of patient autonomy in treatment decision‐making. The aim of this study is to identify factors which influ... Read More about Factors influencing older women's decision‐making related to treatment of operable breast cancer: A qualitative systematic review.

Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network (2023)
Journal Article
Aristei, C., Tomatis, M., Ponti, A., Marotti, L., Cardoso, M. J., Cheung, K. L., Curigliano, G., De Vries, J., Santini, D., Sardanelli, F., Van Dam, P., & Rubio, I. T. (2024). Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network. European Journal of Cancer, 196, Article 113438. https://doi.org/10.1016/j.ejca.2023.113438

Introduction
The present study was designed to describe tumour features and treatments for patients with breast cancer. It also aimed at assessing the risk of distant metastases in relation to biological profiles, disease stages and treatment.
Meth... Read More about Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network.

Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative (2023)
Journal Article
Galvin, A., Soubeyran, P., Brain, E., Cheung, K. L., Hamaker, M. E., Kanesvaran, R., Mauer, M., Mohile, S., Montroni, I., Puts, M., Rostoft, S., Wildiers, H., Mathoulin-Pélissier, S., & Bellera, C. (2023). Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative. Journal of Geriatric Oncology, Article 101611. https://doi.org/10.1016/j.jgo.2023.101611

As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population. Commonly used RCT endpoints for the assessment of treatment efficacy are mor... Read More about Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative.