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Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease (2016)
Journal Article
Hardy, T., Zeybel, M., Day, C. P., Dipper, C., Masson, S., McPherson, S., …Mann, J. (2017). Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. Gut, 66(7), 1321-1328. https://doi.org/10.1136/gutjnl-2016-311526

Objective: Liver biopsy is currently the most reliable way of evaluating liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Its inherent risks limit its widespread use. Differential liver DNA methylation of peroxisome prolifer... Read More about Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease.

Anticipation of thermal pain in diverticular disease (2016)
Journal Article
Smith, J. K., Marciani, L., Humes, D. J., Francis, S. T., Gowland, P. A., & Spiller, R. C. (2016). Anticipation of thermal pain in diverticular disease. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12790

Background The relative importance of peripheral nerve injury or differences in central pain processing in painful diverticular disease (DD) is unclear. Functional MRI has demonstrated changes in the anticipation of pain in irritable bowel syndrom... Read More about Anticipation of thermal pain in diverticular disease.

Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells (2016)
Journal Article
Hussain, K., Letley, D. P., Greenaway, A. B., Kenefeck, R., Winter, J. A., Tomlinson, W., …Robinson, K. (2016). Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells. Frontiers in Immunology, 7, Article 71. https://doi.org/10.3389/fimmu.2016.00071

© 2016 Hussain, Letley, Greenaway, Kenefeck, Winter, Tomlinson, Rhead, Staples, Kaneko, Atherton and Robinson. Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1),... Read More about Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells.

Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation (2016)
Journal Article
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Paul, J., Cox, E., …Spiller, R. C. (2016). Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation. Neurogastroenterology and Motility, 28(6), https://doi.org/10.1111/nmo.12784

Background Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal vol... Read More about Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation.

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis (2016)
Journal Article
Foster, G. R., Irving, W. L., Cheung, M. C., Walker, A. J., Hudson, B. E., Verma, S., …Agarwal, K. (2016). Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis. Journal of Hepatology, 64(6), 1224-1231. https://doi.org/10.1016/j.jhep.2016.01.029

© 2016 European Association for the Study of the Liver. Background & Aims All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared outcom... Read More about Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis.

Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults (2016)
Journal Article
Humes, D., Walker, A. J., Hunt, B., Sultan, A. A., Ludvigsson, J. F., & West, J. (2016). Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults. British Journal of Surgery, 103(4), 443-450. https://doi.org/10.1002/bjs.10091

BACKGROUND: Appendicectomy is the commonest intra-abdominal emergency surgical procedure, and little is known regarding the magnitude and timing of the risk of venous thromboembolism (VTE) after surgery. This study aimed to determine absolute and rel... Read More about Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults.

Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial (2015)
Journal Article

Importance: Case reports and series suggest hematopoietic stem cell transplantation (HSCT) may benefit some patients with Crohn disease. Objective: To evaluate the effect of autologous HSCT on refractory Crohn disease. Design, Setting, and Pa... Read More about Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial.