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Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial (2018)
Journal Article
Jankowski, J. A., de Caestecker, J., Love, S. B., Reilly, G., Watson, P., Sanders, S., …Moayyedi, P. (2018). Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. Lancet, 392(10145), 400-408. https://doi.org/10.1016/S0140-6736%2818%2931388-6

Background: Oesophageal adenocarcinoma (OA) is the sixth commonest cause of cancer death worldwide and Barrett’s oesophagus (BO) is the most significant risk factor. We evaluated the efficacy of high-dose esomeprazole proton pump inhibitor acid suppr... Read More about Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial.

ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis (2018)
Journal Article
Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., …George, J. (2019). ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis. Hepatology, 69(3), 1075-1086. https://doi.org/10.1002/hep.30163

Given the high global prevalence of nonalcoholic fatty liver disease (NAFLD), the need for relevant noninvasive biomarkers and algorithms to accurately stage disease severity is a critical unmet medical need. Identifying those with advanced fibrosis... Read More about ADAPT: an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis.

A comparison of two different software packages for the analysis of body composition using computed tomography images (2018)
Journal Article
Rollins, K. E., Awwad, A., MacDonald, I. A., & Lobo, D. N. (2019). A comparison of two different software packages for the analysis of body composition using computed tomography images. Nutrition, 57, 92-96. https://doi.org/10.1016/j.nut.2018.06.003

Objectives: Body composition analysis from computed tomography (CT) imaging has become widespread. However, the methodology used is far from established. Two main software packages are in common usage for body composition analysis, with results used... Read More about A comparison of two different software packages for the analysis of body composition using computed tomography images.

Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon (2018)
Journal Article
Spiller, R. C. (2018). Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon. Cellular and Molecular Gastroenterology and Hepatology, 6(3), 347–348.e1. https://doi.org/10.1016/j.jcmgh.2018.06.005

As we learn more about the importance of our microbiome in inflammatory, metabolic, and functional disorders, we are coming to appreciate the risks of disturbing this with broad-spectrum antibiotics. We have known for many years that as antibiotics h... Read More about Hidden dangers of antibiotic use: increased gut permeability mediated by increased pancreatic proteases reaching the colon.

All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis (2018)
Journal Article
Abdul-Rahman, A.-K., Card, T. R., Grainge, M. J., & Fleming, K. M. (2018). All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis. Substance Abuse, 39(4), 509-517. https://doi.org/10.1080/08897077.2018.1475318

Background Although alcohol use disorders (AUD) are known to increase the relative risk of all-cause and some cause-specific mortalities, the absolute mortality rates of the AUD population are unknown. Such knowledge would benefit planners of the pr... Read More about All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis.

Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation (2018)
Journal Article
Fainberg, H. P., Birtwistle, M., Alagal, R., Alhaddad, A., Pope, M., Davies, G., …Symonds, M. E. (2018). Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation. Scientific Reports, 8(1), 1-11. https://doi.org/10.1038/s41598-018-27376-3

Brown adipose tissue (BAT) undergoes pronounced changes after birth coincident with the loss of the BAT-specifc uncoupling protein (UCP)1 and rapid fat growth. The extent to which this adaptation may vary between anatomical locations remains unknown,... Read More about Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation.

Systematic review of the evidence for sustained efficacy of dietary interventions for reducing appetite or energy intake (2018)
Journal Article
Halford, J. C., Masic, U., Marseaux, C. F., Jones, A. J., Lluch, A., Marciani, L., …Mela, D. J. (2018). Systematic review of the evidence for sustained efficacy of dietary interventions for reducing appetite or energy intake. Obesity Reviews, 19(10), 1329-1339. https://doi.org/10.1111/obr.12712

We assessed evidence for changes in efficacy of food-based interventions aimed at reducing appetite or energy intake (EI), and whether this could be used to provide guidance on trial design. A systematic search identified randomized controlled tria... Read More about Systematic review of the evidence for sustained efficacy of dietary interventions for reducing appetite or energy intake.

Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ project (2018)
Journal Article
Hens, B., Sinko, P., Job, N., Dean, M., Al-Gousous, J., Salehi, N., …Amidon, G. L. (2018). Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ project. International Journal of Pharmaceutics, 548(1), https://doi.org/10.1016/j.ijpharm.2018.06.050

Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by perf... Read More about Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ project.

A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection (2018)
Journal Article
Negm, O. H., Hamed, M. R., & Monaghan, T. M. (2018). A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection. Journal of Visualized Experiments, 2018(136), Article e57399. https://doi.org/10.3791/57399

We provide a detailed overview of a novel high-throughput protein microarray assay for the determination of anti-C. difficile antibody levels in human sera and in separate preparations of polyclonal IVIg. The protocol describes the methodological ste... Read More about A protein microarray assay for serological determination of antigen-specific antibody responses following Clostridium difficile infection.