Outputs (3)

M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β (2022)
Journal Article
Asanprakit, W., Lobo, D. N., Eremin, O., & Bennett, A. J. (2022). M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β. Scientific Reports, 12(1), Article 16842. https://doi.org/10.1038/s41598-022-20811-6

High expression of polymeric immunoglobulin receptor (PIGR) in breast cancer is associated with increased 5-year survival rate. However, the factors influencing PIGR expression in breast cancer have not been elucidated. The aim of this study was to d... Read More about M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.

Integrins as a drug target in liver fibrosis (2022)
Journal Article
Rahman, S. R., Roper, J. A., Grove, J. I., Aithal, G. P., Pun, K. T., & Bennett, A. J. (2022). Integrins as a drug target in liver fibrosis. Liver International, 42(3), 507-521. https://doi.org/10.1111/liv.15157

As the worldwide prevalence of chronic liver diseases is high and continuing to increase, there is an urgent need for treatment to prevent cirrhosis-related morbidity and mortality. Integrins are heterodimeric cell-surface proteins that are promising... Read More about Integrins as a drug target in liver fibrosis.

Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine (2021)
Journal Article
Jalanka, J., Lam, C., Bennett, A., Hartikainen, A., Crispie, F., Finnegan, L. A., Cotter, P. D., & Spiller, R. (2021). Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine. Journal of Neurogastroenterology and Motility, 27(2), 279-291. https://doi.org/10.5056/JNM20205

Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammator... Read More about Colonic gene expression and fecal microbiota in diarrhea-predominant irritable bowel syndrome: Increased toll-like receptor 4 but minimal inflammation and no response to mesalazine.