Outputs (102)

Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes (2020)
Journal Article
Chadborn, N. H., Devi, R., Hinsliff-Smith, K., Banerjee, J., & Gordon, A. L. (2021). Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes. European Geriatric Medicine, 12, 17-26. https://doi.org/10.1007/s41999-020-00389-w

Purpose
We conducted a scoping review of quality improvement in care homes. We aimed to identify participating occupational groups and methods for evaluation. Secondly, we aimed to describe resident-level interventions and which outcomes were measur... Read More about Quality improvement in long-term care settings: a scoping review of effective strategies used in care homes.

Development of a Malaysian Undergraduate Geriatric Medicine Curriculum (2020)
Journal Article
Sallehuddin, H., Tan, M. P., Blundell, A., Gordon, A. L., & Masud, T. (2020). Development of a Malaysian Undergraduate Geriatric Medicine Curriculum. Aging Medicine and Healthcare, 11(3), 82-88. https://doi.org/10.33879/AMH.113.2020.05015

Objective: Malaysia is only beginning to age in 2020, but is expected to do this at an unprecedented rate in the next two decades. We aim to develop a national curriculum for undergraduate geriatric medicine in Malaysia to ensure future doctors are a... Read More about Development of a Malaysian Undergraduate Geriatric Medicine Curriculum.

Clinical relevance of biomarkers in oestrogen receptor positive breast cancer (2020)
Book Chapter
Parks, R. M., & Cheung, K. L. (2020). Clinical relevance of biomarkers in oestrogen receptor positive breast cancer. In G. G. Chen, M. C. Tong, & C. van Hasselt (Eds.), Estrogen receptors: structure, functions and clinical aspects (53-91). Nova Science Publishers

© 2020 Nova Science Publishers, Inc. Some biomarkers have been examined extensively in the context of breast cancer, including the oestrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). They are now routinely measured and used c... Read More about Clinical relevance of biomarkers in oestrogen receptor positive breast cancer.

Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study (2020)
Journal Article
Izza, M. A. D., Lunt, E., Gordon, A. L., Gladman, J. R. F., Armstrong, S., & Logan, P. A. (2020). Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study. European Geriatric Medicine, 11, 1043-1050. https://doi.org/10.1007/s41999-020-00376-1

Purpose: Falls and polypharmacy are both common in care home residents. Deprescribing of medications in residents with increased falls risk is encouraged. Psychotropic medications are known to increase falls risk in older adults. These drugs are ofte... Read More about Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study.

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 (2020)
Journal Article
Hounkpatin, H. O., Harris, S., Fraser, S. D., Day, J., Mindell, J. S., Taal, M. W., O’Donoghue, D., & Roderick, P. J. (2020). Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016. BMJ Open, 10(8), Article e038423. https://doi.org/10.1136/bmjopen-2020-038423

Objectives: To identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic, behavioural and clinical factors.
Design: Pooled cross-sectional analysis.
Setting: Health... Read More about Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016.

The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ (2020)
Journal Article
Miligy, I. M., Toss, M. S., Shiino, S., Oni, G., Syed, B. M., Khout, H., Tan, Q., Green, A. R., Macmillan, R. D., Robertson, J. F. R., & Rakha, E. A. (2020). The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ. British Journal of Cancer, 123(10), 1513-1520. https://doi.org/10.1038/s41416-020-1023-3

Background: Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of out... Read More about The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ.

Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article
Fraser, S. D., Barker, J., Roderick, P. J., Yuen, H. M., Shardlow, A., Morris, J. E., McIntyre, N. J., Fluck, R. J., McIntyre, C. W., & Taal, M. W. (2020). Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study. BMJ Open, 10, Article e040286. https://doi.org/10.1136/bmjopen-2020-040286

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care.

Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States (2020)
Journal Article
Stokes, T., Timmons, J. A., Crossland, H., Tripp, T. R., Murphy, K., McGlory, C., Mitchell, C. J., Oikawa, S. Y., Morton, R. W., Phillips, B. E., Baker, S. K., Atherton, P. J., Wahlestedt, C., & Phillips, S. M. (2020). Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States. Cell Reports, 32(5), Article 107980. https://doi.org/10.1016/j.celrep.2020.107980

Loading of skeletal muscle changes the tissue phenotype reflecting altered metabolic and functional demands. In humans, heterogeneous adaptation to loading complicates the identification of the underpinning molecular regulators. A within-person diffe... Read More about Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States.

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle (2020)
Journal Article
Abdulla, H., Phillips, B. E., Wilkinson, D. J., Limb, M., Jandova, T., Bass, J. J., Rankin, D., Cegielski, J., Sayda, M., Crossland, H., Williams, J. P., Smith, K., Idris, I., & Atherton, P. J. (2020). Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging Cell, 19(9), Article e13202. https://doi.org/10.1111/acel.13202

© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd Background: Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-stat... Read More about Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome (2020)
Journal Article
Parks, R. M., Albanghali, M., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2020). Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome. Cancers, 12(8), Article 2067. https://doi.org/10.3390/cancers12082067

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The majority of biological profiling studies use surgical excision (SE) samples, excluding patients receiving nonsurgical and neoadjuvant therapy. We propose using core needle biopsy (CNB) for... Read More about Biology of oestrogen-receptor positive primary of core needle biopsy samples and correlation with clinical outcome.