Outputs (102)

USING INTERNATIONAL COLLABORATIONS TO SHAPE RESEARCH AND INNOVATION INTO CARE HOMES IN BRAZIL: A WHITE PAPER (2020)
Journal Article
Jacinto, A. F., Achterberg, W., Wachholz, P. A., Dening, T., Dening, K. H., Devi, R., Oliveira, D., Everink, I., Azevedo, P. S., Villas Boas, P. J., Hinsliff-Smith, K., Hoedl, M., Schols, J. M., Shepherd, V., Gratao, A., Watanabe, H. A., Zazzetta, M. S., Goodman, C., Spilsby, K., & Gordon, A. (2020). USING INTERNATIONAL COLLABORATIONS TO SHAPE RESEARCH AND INNOVATION INTO CARE HOMES IN BRAZIL: A WHITE PAPER. Journal of Nursing Home Research, 6(109-113), https://doi.org/10.14283/jnhrs.2020.28

The Brazilian care home sector is underdeveloped, and the limited available evidence suggests that care quality falls below international standards. Development of the Brazilian care home sector could be associated with better outcomes for those rece... Read More about USING INTERNATIONAL COLLABORATIONS TO SHAPE RESEARCH AND INNOVATION INTO CARE HOMES IN BRAZIL: A WHITE PAPER.

Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray (2020)
Journal Article
Parks, R. M., Albanghali, M. A., Syed, B. M., Green, A. R., Ellis, I. O., & Cheung, K. L. (2021). Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray. Breast Cancer Research and Treatment, 185(3), 647-655. https://doi.org/10.1007/s10549-020-06023-4

© 2020, The Author(s). Purpose: Prediction of response to primary endocrine therapy (PET) in older women is based on measurement of oestrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor (HER)-2. This study uses a uniq... Read More about Patterns of biomarker expression in patients treated with primary endocrine therapy – a unique insight using core needle biopsy tissue microarray.

Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life (2020)
Journal Article
Wyld, L., Reed, M. W., Morgan, J., Collins, K., Ward, S., Holmes, G. R., Bradburn, M., Walters, S., Burton, M., Herbert, E., Lifford, K., Edwards, A., Ring, A., Robinson, T., Martin, C., Chater, T., Pemberton, K., Shrestha, A., Brennan, A., Cheung, K. L., …Thomson, A. M. (2021). Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life. European Journal of Cancer, 142, 48-62. https://doi.org/10.1016/j.ejca.2020.10.015

Background: Age-related breast cancer treatment variance is widespread with many older women having primary endocrine therapy (PET), which may contribute to inferior survival and local control. This propensity-matched study determined if a subgroup o... Read More about Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life.

Potential nutraceutical properties of leaves from several commonly cultivated plants (2020)
Journal Article
Amat-ur-Rasool, H., Symes, F., Tooth, D., Schaffert, L.-N., Elmorsy, E., Ahmed, M., Hasnain, S., & Carter, W. G. (2020). Potential nutraceutical properties of leaves from several commonly cultivated plants. Biomolecules, 10(11), 1-22. https://doi.org/10.3390/biom10111556

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase i... Read More about Potential nutraceutical properties of leaves from several commonly cultivated plants.

Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle (2020)
Journal Article
Guo, Y., Phillips, B. E., Atherton, P. J., & Piasecki, M. (2021). Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle. Mechanisms of Ageing and Development, 193, Article 111402. https://doi.org/10.1016/j.mad.2020.111402

One of the most notable effects of ageing is an accelerated decline of skeletal muscle mass and function, resulting in various undesirable outcomes such as falls, frailty, and all-cause mortality. The loss of muscle mass directly leads to functional... Read More about Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle.

A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis (2020)
Journal Article
Stewart, J., Stewart, P., Walker, T., Horner, D. V., Lucas, B., White, K., Muggleton, A., Morris, M., Selby, N. M., & Taal, M. W. (2021). A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis. IEEE Journal of Translational Engineering in Health and Medicine, 9, 1-1. https://doi.org/10.1109/JTEHM.2020.3035988

Objective: Intradialytic haemodynamic instability is a significant clinical problem, leading to end-organ ischaemia and contributing to morbidity and mortality in haemodialysis patients. Non-invasive continuous blood pressure monitoring is not curren... Read More about A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis.

August 2020 Interim EuGMS guidance to prepare European Long-Term Care Facilities for COVID-19 (2020)
Journal Article
Blain, H., Rolland, Y., Schols, J. M. G. A., Cherubini, A., Miot, S., O'Neill, D., Martin, F. C., Guérin, O., Gavazzi, G., Bousquet, J., Petrovic, M., Gordon, A. L., & Benetos, A. (2020). August 2020 Interim EuGMS guidance to prepare European Long-Term Care Facilities for COVID-19. European Geriatric Medicine, 11(6), Article 899-813. https://doi.org/10.1007/s41999-020-00405-z

Purpose: The European Geriatric Medicine Society (EuGMS) is launching its second interim guidance with the aim to prevent the entrance and spread of COVID-19 into long-term care facilities (LTCFs).

Methods: The EuGMS gathered experts with relevan... Read More about August 2020 Interim EuGMS guidance to prepare European Long-Term Care Facilities for COVID-19.

Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial (2020)
Journal Article
Smith, I., Robertson, J., Kilburn, L., Wilcox, M., Evans, A., Holcombe, C., Horgan, K., Kirwan, C., Mallon, E., Sibbering, M., Skene, A., Vidya, R., Cheang, M., Banerji, J., Morden, J., Sidhu, K., Dodson, A., Bliss, J. M., & Dowsett, M. (2020). Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial. Lancet Oncology, 21(11), 1443-1454. https://doi.org/10.1016/S1470-2045%2820%2930458-7

Background: Preoperative and perioperative aromatase inhibitor (POAI) therapy has the potential to improve outcomes in women with operable oestrogen receptor-positive primary breast cancer. It has also been suggested that tumour Ki67 values after 2 w... Read More about Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial.

Diuretics and risk of lower extremity amputation amongst patients with insulin-treated type 2 diabetes – exploring the mechanism of possible sodium glucose co-transporter 2 inhibitor induced risk of lower extremity amputations (2020)
Journal Article
Alshnbari, A., Alkharaiji, M., Anyanwagu, U., & Idris, I. (2020). Diuretics and risk of lower extremity amputation amongst patients with insulin-treated type 2 diabetes – exploring the mechanism of possible sodium glucose co-transporter 2 inhibitor induced risk of lower extremity amputations. Current Medical Research and Opinion, 36(12), 1985-1989. https://doi.org/10.1080/03007995.2020.1840340

Aims and background: Sodium-glucose cotransporter-2 (SGLT2) inhibitor has been linked to an increased risk of lower extremity amputation (LEA) in patients with Type 2 Diabetes (T2D) and is known to induce volume depletion through osmotic diuresis. We... Read More about Diuretics and risk of lower extremity amputation amongst patients with insulin-treated type 2 diabetes – exploring the mechanism of possible sodium glucose co-transporter 2 inhibitor induced risk of lower extremity amputations.

Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance (2020)
Journal Article
Campbell, C., Mathew, J., Ellis, I. O., Bradbury, I., Borgquist, S., Elebro, K., Green, A. R., Finlay, P., Gee, J. M. W., & Robertson, J. F. R. (2020). Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance. Translational Breast Cancer Research, 1, Article 29. https://doi.org/10.21037/tbcr-20-31

Background: It remains clinically important to identify ER positive breast cancers likely to respond to tamoxifen (TAM) and so we aimed to select a group of biomarkers able to predict response. We also assessed whether data from different sample type... Read More about Markers of steroid receptor, kinase signalling pathways and Ki-67 expression in relation to tamoxifen sensitivity and resistance.