Outputs (19)

Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial (2016)
Journal Article
Johnson, S. L., Szigeti, M., Cross, M., Brightling, C., Chaudhuri, R., Harrison, T. W., Mansur, A., Robison, L., Sattar, Z., Jackson, D., Mallia, P., Wong, E., Corrigan, C., Higgins, B., Ind, P., Singh, D., Thomson, N. C., Ashby, D., & Chauhan, A. (2016). Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial. JAMA Internal Medicine, 176(11), https://doi.org/10.1001/jamainternmed.2016.5664

IMPORTANCE Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use.
OBJECTIVE To determine whether azithromycin added to standard care for asthma attacks i... Read More about Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial.

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2016, 1-9. https://doi.org/10.1155/2016/3604842

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More about Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma (2016)
Journal Article
Malkar, A., Wilson, E., Harrison, T., Shaw, D. E., & Creaser, C. (in press). Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma. Analytical Methods, 8(27), 5407-5413. https://doi.org/10.1039/C6AY00938G

Current clinical tests employed to diagnose asthma are inaccurate and limited by their invasive nature. New metabolite profiling technologies offer an opportunity to improve asthma diagnosis using non-invasive sampling. A rapid analytical method for... Read More about Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma.

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., Kelly, A.-M., & Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. https://doi.org/10.1136/thoraxjnl-2015-207573

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.

A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA) (2015)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Meakin, G., Bailey, H., Pavord, I., Shaw, D. E., & Harrison, T. W. (2015). A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA). Thorax, 70(6), 559-565. https://doi.org/10.1136/thoraxjnl-2014-206481

Background: Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an e... Read More about A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA).

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., Thornton, J., Harrison, T. W., Knox, A. J., & Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061

BACKGROUND:

There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study (2014)
Journal Article
Meakin, G., Anderson, J., McKeever, T., Wilson, E., McKeever, T. M., Hargadon, B., Hearson, G., Anderson, J., Hodgson, D., Bailey, H., Meakin, G., Thomas, M., Pavord, I. D., Harrison, T. W., & Shaw, D. E. (2014). Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study. European Respiratory Journal, 44(6), 1705-1707. https://doi.org/10.1183/09031936.00093614

Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations (2014)
Journal Article
Bateman, E. D., Buhl, R., O’Byrne, P. M., Humbert, M., Reddel, H. K., Sears, M. R., Jenkins, C., Harrison, T. W., Quirce, S., Peterson, S., & Eriksson, G. (2015). Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations. Journal of Allergy and Clinical Immunology, 135(6), 1457-1464. https://doi.org/10.1016/j.jaci.2014.08.015

The impact of azithromycin therapy on the airway microbiota in asthma (2014)
Journal Article
Slater, M., Rivett, D. W., Williams, L., Martin, M., Harrison, T. W., Sayers, I., Bruce, K. D., & Shaw, D. E. (2014). The impact of azithromycin therapy on the airway microbiota in asthma. Thorax, 69(7), https://doi.org/10.1136/thoraxjnl-2013-204517

There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a... Read More about The impact of azithromycin therapy on the airway microbiota in asthma.