Skip to main content

Research Repository

Advanced Search

Outputs (802)

Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus (2003)
Journal Article
Dell, G., Wilkinson, K. W., Tranter, R., Parish, J., Brady, R. L., & Gaston, K. (2003). Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus. Journal of Molecular Biology, 334(5), 979-991. https://doi.org/10.1016/j.jmb.2003.10.009

Human papillomaviruses (HPVs) that infect the genital tract can be divided into two groups: high-risk HPV types, such as HPV 16 and HPV 18, are associated with cancer, low-risk HPV types, such as HPV 6, are associated with benign warts. In both high-... Read More about Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus.

Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulva intraepithelial neoplasia (2003)
Journal Article
Davidson, E. J., Sehr, P., Faulkner, R. L., Parish, J. L., Gaston, K., Moore, R. A., Pawlita, M., Kitchener, H. C., & Stern, P. L. (2003). Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulva intraepithelial neoplasia. Journal of General Virology, 84(8), 2089-2097. https://doi.org/10.1099/vir.0.19095-0

The transcriptional repressor protein PRH interacts with the proteasome (2003)
Journal Article
Bess, K. L., Swingler, T. E., Rivett, A. J., Gaston, K., & Jayaraman, P.-S. (2003). The transcriptional repressor protein PRH interacts with the proteasome. Biochemical Journal, 374(3), 667-675. https://doi.org/10.1042/BJ20030769

PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomai... Read More about The transcriptional repressor protein PRH interacts with the proteasome.

Transcriptional repression in eukaryotes: repressors and repression mechanisms (2003)
Journal Article
Gaston, K., & Jayaraman, P.-S. (2003). Transcriptional repression in eukaryotes: repressors and repression mechanisms. Cellular and Molecular Life Sciences, 60(4), 721-741. https://doi.org/10.1007/s00018-003-2260-3

For many, if not most genes, the initiation of transcription is the principle point at which their expression is regulated. Transcription factors, some of which bind to specific DNA sequences, generally either activate or repress promoter activity an... Read More about Transcriptional repression in eukaryotes: repressors and repression mechanisms.

Purification of the proline-rich homeodomain protein (2002)
Journal Article
Butcher, A. J., Gaston, K., & Jayaraman, P.-S. (2003). Purification of the proline-rich homeodomain protein. Journal of Chromatography B, 786(1-2), 3-6. https://doi.org/10.1016/S1570-0232%2802%2900740-7

The proline-rich homeodomain protein (PRH), also known as Hex, is a transcriptional repressor expressed in a variety of cell types. The PRH protein contains a proline-rich N-terminal domain that can repress transcription when attached to a heterologo... Read More about Purification of the proline-rich homeodomain protein.

The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance (2002)
Journal Article
Rees, L., Wood, N., Gillespie, K., Lai, K., Gaston, K., & Mathieson, P. (2002). The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance. Cellular and Molecular Life Sciences, 59(3), 560-569. https://doi.org/10.1007/s00018-002-8448-0

Genotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position -1082 has been linked to... Read More about The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance.

Combination of progesterone and mifepristone for cancer therapy (2001)
Other
Gaston, K. (2001). Combination of progesterone and mifepristone for cancer therapy. n/a

Use of a steroid hormone or steroid hormone analogue and at least a portioUse of a steroid hormone or steroid hormone analogue and at least a portion of HPV E2 protein in the preparation of a pharmaceutical composition for the treatment of cervical c... Read More about Combination of progesterone and mifepristone for cancer therapy.

Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells (2001)
Journal Article
Davidson, E. J., Brown, M. D., Burt, D. J., Parish, J. L., Gaston, K., Kitchener, H. C., Stacey, S. N., & Stern, P. L. (2001). Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells. International Journal of Cancer, 94(6), 807-812. https://doi.org/10.1002/ijc.1558

Persistent infection with human papillomavirus (HPV) type 16 has been implicated in the etiology of cervical cancer. The E2 protein is required early in viral infection and therefore may serve as a useful immune target for a vaccine aimed at preventi... Read More about Human T-cell responses to HPV 16 E2 generated with monocyte-derived dendritic cells.

Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer (2001)
Journal Article
Dell, G., & Gaston, K. (2001). Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer. Cellular and Molecular Life Sciences, 58(12), 1923-1942. https://doi.org/10.1007/pl00000827

Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer of the cervix, a disease responsible for at least 200,000 deaths per year worldwide. Over 100 different types of HPV have been identified and these can... Read More about Contributions in the domain of cancer research: Review¶Human papillomaviruses and their role in cervical cancer.