Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
(2015)
Journal Article
Sampaziotis, F., Cardoso de Brito, M., Madrigal, P., Bertero, A., Saeb-Parsy, K., Soares, F. A., Schrumpf, E., Melum, E., Karlsen, T. H., Bradley, J. A., Gelson, W. T., Davies, S., Baker, A., Kaser, A., Alexander, G. J., Hannan, N. R., & Vallier, L. (in press). Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology, 33(8), https://doi.org/10.1038/nbt.3275
The study of biliary disease has been constrained by a lack of primary human cholangiocytes. Here we present an efficient, serum-free protocol for directed differentiation of human induced pluripotent stem cells into cholangiocyte-like cells (CLCs).... Read More about Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.