Outputs (13)

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy (2016)
Journal Article
Crittenden, M. R., Baird, J., Friedman, D., Savage, T., Uhde, L., Alice, A., Cottam, B., Young, K., Newell, P., Nguyen, C., Bambina, S., Cramer, G., Akporiaye, E., Malecka, A., Jackson, A., & Gough, M. J. (2016). Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy. Oncotarget, 7(48), 78653-78666. https://doi.org/10.18632/oncotarget.11823

Radiation therapy provides a means to kill large numbers of cancer cells in a controlled location resulting in the release of tumor-specific antigens and endogenous adjuvants. However, by activating pathways involved in apoptotic cell recognition and... Read More about Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy.

Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation (2016)
Journal Article
Malecka, A., Wang, O., Shah, S., Sutavani, R. V., Spendlove, I., Ramage, J. M., Greensmith, J., Franks, H. A., Gough, M. J., Saalbach, A., Patel, P. M., & Jackson, A. M. (2016). Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation. Journal of Leukocyte Biology, 100(2), 381-389. https://doi.org/10.1189/jlb.3A1015-474R

Dendritic cell function is modulated by stromal cells, including fibroblasts. Although poorly understood, the signals delivered through this crosstalk substantially alter dendritic cell biology. This is well illustrated with release of TNF-0/IL-113 f... Read More about Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation.

Impact of p38 mitogen-activated protein kinase inhibition on immunostimulatory properties of human 6-sulfo LacNAc dendritic cells (2015)
Journal Article
Langosch, S., Wehner, R., Malecka, A., Franks, H. A., Schäkel, K., Bachmann, M., Jackson, A. M., & Schmitz, M. (2016). Impact of p38 mitogen-activated protein kinase inhibition on immunostimulatory properties of human 6-sulfo LacNAc dendritic cells. Immunobiology, 221(2), 166-174. https://doi.org/10.1016/j.imbio.2015.09.012

p38 Mitogen-activated protein kinase (MAPK) plays a crucial role in the induction and regulation of innate and adaptive immunity. Furthermore, p38 MAPK can promote tumor invasion, metastasis, and angiogenesis. Based on these properties, p38 MAPK inhi... Read More about Impact of p38 mitogen-activated protein kinase inhibition on immunostimulatory properties of human 6-sulfo LacNAc dendritic cells.