Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST
(2018)
Journal Article
McKeever, T., Mortimer, K., Bradshaw, L., Haydock, R., Pavord, I., Higgins, B., Walker, S., Wilson, A., Price, D., Thomas, M., Devereux, G., Brightling, C., Renwick, C., Parrott, S., Mitchell, E., Duley, L., & Harrison, T. (2018). Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST. Health Technology Assessment, 22(70), 1-82. https://doi.org/10.3310/hta22700
Outputs (6)
Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations (2018)
Journal Article
McKeever, T., Mortimer, K., Wilson, A., Walker, S., Brightling, C., Skeggs, A., Pavord, I., Price, D., Duley, L., Thomas, M., Bradshaw, L., Higgins, B., Haydock, R., Mitchell, E., Devereux, G., & Harrison, T. (2018). Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. New England Journal of Medicine, 378(10), 902-910. https://doi.org/10.1056/NEJMoa1714257Copyright © 2018 Massachusetts Medical Society. BACKGROUND Asthma exacerbations are frightening for patients and are occasionally fatal. We tested the concept that a plan for patients to manage their asthma (self-management plan), which included a te... Read More about Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations.
FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations (2016)
Journal Article
Skeggs, A., McKeever, T. M., Duley, L., Mitchell, E., Bradshaw, L., Mortimer, K., Walker, S., Parrott, S., Wilson, A., Pavord, I., Brightling, C., Thomas, M., Price, D., Devereux, G., Higgins, B., Harrison, T. W., & Haydock, R. (2016). FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations. Trials, 17, https://doi.org/10.1186/s13063-016-1608-6BACKGROUND: Asthma is one of the commonest chronic diseases in the UK. Acute exacerbations of asthma are unpredictable, disruptive and frightening. They cause considerable morbidity and account for a large component of the health service costs of ast... Read More about FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.
Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., Kelly, A.-M., & Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. https://doi.org/10.1136/thoraxjnl-2015-207573Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.
Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article
John, M., Cockcroft, J. R., McKeever, T. M., Coward, W. R., Shale, D. J., Johnson, S. R., Thornton, J., Harrison, T. W., Knox, A. J., & Bolton, C. E. (2015). Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. International Journal of Chronic Obstructive Pulmonary Disease, 10(1), https://doi.org/10.2147/COPD.S76061BACKGROUND:
There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..
Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study (2014)
Journal Article
Meakin, G., Anderson, J., McKeever, T., Wilson, E., McKeever, T. M., Hargadon, B., Hearson, G., Anderson, J., Hodgson, D., Bailey, H., Meakin, G., Thomas, M., Pavord, I. D., Harrison, T. W., & Shaw, D. E. (2014). Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study. European Respiratory Journal, 44(6), 1705-1707. https://doi.org/10.1183/09031936.00093614