Outputs (1135)

The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness (2022)
Journal Article
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Hogan, N., Buggy, N., Van de Heyning, P. H., Firszt, J. B., Bruce, I. A., Kitterick, P. T., & for the Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) initiative. (2022). The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness. Trials, 23(1), Article 764. https://doi.org/10.1186/s13063-022-06702-1

Background: Single-sided deafness (SSD) has functional, psychological, and social consequences. Interventions for adults with SSD include hearing aids and auditory implants. Benefits and harms (outcome domains) of these interventions are until now re... Read More about The Core Rehabilitation Outcome Set for Single-Sided Deafness (CROSSSD) study: International consensus on outcome measures for trials of interventions for adults with single-sided deafness.

Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland (2022)
Journal Article
Kwok, T. C., Dineen, R. A., Whitehouse, W., Lynn, R. M., McSweeney, N., & Sharkey, D. (2022). Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland. Open Medicine, 17(1), 1417-1424. https://doi.org/10.1515/med-2022-0554

Neonatal stroke is a devastating condition that causes brain injury in babies and often leads to lifelong neurological impairment. Recent prospective population studies of neonatal stroke are lacking. Neonatal strokes are different from those in olde... Read More about Neonatal stroke surveillance study protocol in the United Kingdom and Republic of Ireland.

Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850) (2022)
Journal Article
Bath, P. M., Mhlanga, I., Woodhouse, L. J., Doubal, F., Oatey, K., Montgomery, A. A., Wardlaw, J. M., & LACI-2 Trial Investigators. (2023). Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850). Stroke and Vascular Neurology, 8, Article e001816. https://doi.org/10.1136/svn-2022-001816

Background: Cerebral small vessel disease (SVD) causes lacunar strokes (25% of all ischaemic strokes), physical frailty and cognitive impairment and vascular and mixed dementia. There is no specific treatment to prevent progression of SVD. Methods: T... Read More about Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850).

Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms (2022)
Journal Article
Kadir, R. R. A., Alwjwaj, M., Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2022). Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms. Stem Cell Reviews and Reports, https://doi.org/10.1007/s12015-022-10439-4

Improved understanding of the key mechanisms underlying cerebral ischemic injury is essential for the discovery of efficacious novel therapeutics for stroke. Through detailed analysis of plasma samples obtained from a large number of healthy voluntee... Read More about Outgrowth Endothelial Cell Conditioned Medium Negates TNF-α-Evoked Cerebral Barrier Damage: A Reverse Translational Research to Explore Mechanisms.

A qualitative investigation of the hearing and hearing-aid related emotional states experienced by adults with hearing loss (2022)
Journal Article
Holman, J. A., Ali, Y. H. K., & Naylor, G. (2022). A qualitative investigation of the hearing and hearing-aid related emotional states experienced by adults with hearing loss. International Journal of Audiology, 62(10), 973-982. https://doi.org/10.1080/14992027.2022.2111373

Objective: Despite previous research into the psychosocial impact of hearing loss, little detail is known regarding the hearing and hearing-aid-related emotional states experienced by adults with hearing loss in everyday life, and how they occur. Des... Read More about A qualitative investigation of the hearing and hearing-aid related emotional states experienced by adults with hearing loss.

Development of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study) (2022)
Journal Article
Shepherd, V., Islam, I., Wood, F., Williamson, P. R., Goodman, C., Bath, P. M., Thompson, C., Knapp, M., Gordon, A. L., & Hood, K. (2022). Development of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study). BMC Geriatrics, 22(1), Article 710. https://doi.org/10.1186/s12877-022-03395-8

Background: People living in care homes have experienced devastating impact from COVID-19. As interventions to prevent the transmission of COVID-19 are developed and evaluated, there is an urgent need for researchers to agree on the outcomes used whe... Read More about Development of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study).

Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion (2022)
Journal Article
Seiffge, D. J., Polymeris, A. A., Law, Z. K., Krishnan, K., Zietz, A., Thilemann, S., Werring, D., Al-Shahi Salman, R., Dineen, R. A., Engelter, S. T., Bath, P. M., Sprigg, N., Lyrer, P., & Peters, N. (2022). Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion. Annals of Neurology, 92(6), 921-930. https://doi.org/10.1002/ana.26481

Objective: We assessed whether hematoma expansion (HE) and favorable outcome differ according to type of intracerebral hemorrhage (ICH). Methods: Among participants with ICH enrolled in the TICH-2 (Tranexamic Acid for Hyperacute Primary Intracerebral... Read More about Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion.

Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis (2022)
Journal Article
Meaton, I., Altokhis, A., Allen, C. M., Clarke, M. A., Sinnecker, T., Meier, D., Enzinger, C., Calabrese, M., De Stefano, N., Pitiot, A., Giorgio, A., Schoonheim, M. M., Paul, F., Pawlak, M. A., Schmidt, R., Granziera, C., Kappos, L., Montalban, X., Rovira, À., Wuerfel, J., & Evangelou, N. (2022). Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis. Multiple Sclerosis Journal, https://doi.org/10.1177/13524585221118677

Background: White matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in multiple sclerosis (MS) may contribute to misdiagnosis. In chronic active lesions, peripheral iron-laden macrophages appear as paramagnetic rim lesions (PRLs). Objec... Read More about Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis.

The role of temporal coherence and temporal predictability in the build-up of auditory grouping (2022)
Journal Article
Sollini, J., Poole, K. C., Blauth-Muszkowski, D., & Bizley, J. K. (2022). The role of temporal coherence and temporal predictability in the build-up of auditory grouping. Scientific Reports, 12, Article 14493. https://doi.org/10.1038/s41598-022-18583-0

The cochlea decomposes sounds into separate frequency channels, from which the auditory brain must reconstruct the auditory scene. To do this the auditory system must make decisions about which frequency information should be grouped together, and wh... Read More about The role of temporal coherence and temporal predictability in the build-up of auditory grouping.

Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study (2022)
Journal Article
Spencer, S., Mielczarek, M., Olszewski, J., Sereda, M., Joossen, I., Vermeersch, H., Gilles, A., & Michiels, S. (2022). Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study. Frontiers in Neuroscience, 16, Article 971633. https://doi.org/10.3389/fnins.2022.971633

Background: Tinnitus is a common symptom, affecting about 10–15% of the adult population. When input from the somatosensory system can influence and/or elicit tinnitus, this type of subjective tinnitus is called somatosensory tinnitus. Recently, a ne... Read More about Effectiveness of bimodal auditory and electrical stimulation in patients with tinnitus: A feasibility study.