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Outputs (150)

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial (2018)
Journal Article
Al-Shahi Salman, R., Dennis, M. S., Murray, G. D., Innes, K., Drever, J., Dinsmore, L., …Werring, D. J. (2018). The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19(1), Article 162. https://doi.org/10.1186/s13063-018-2542-6

Background For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is... Read More about The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial.

Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains (2018)
Journal Article
Smith, H., Horobin, A. J., Fackrell, K., Colley, V., Thacker, B., & Hall, D. A. (2018). Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains. Research Involvement and Engagement, 4(8), https://doi.org/10.1186/s40900-018-0091-5

Background Tinnitus is a complex audiological condition affecting many different domains of everyday life. Clinical trials of tinnitus interventions measure and report those outcome domains inconsistently and this hinders direct comparison between s... Read More about Defining and evaluating novel procedures for involving patients in Core Outcome Set research: creating a meaningful long list of candidate outcome domains.

Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important? (2018)
Journal Article
Hall, D. A., Mehta, R., & Argstatter, H. (2018). Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important?. International Journal of Audiology, 57(7), 553-557. https://doi.org/10.1080/14992027.2018.1442591

Objective: Reporting of clinical significance is recommended because findings can be statistically significant without being relevant to patients. For aiding clinical interpretation of the Tinnitus Questionnaire (TQ), many investigators use a 5-point... Read More about Interpreting the Tinnitus Questionnaire (German version):what individual differences are clinically important?.

The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved] (2018)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P. M., Kang Law, Z., …Roberts, I. (2018). The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.2

© 2018 Ker K et al. Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials.... Read More about The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 2; peer review: 2 approved].

Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics (2018)
Journal Article
Sanderson, M., Chikhani, M., Blyth, E., Wood, S., Moppett, I. K., McKeever, T., & Simmonds, M. J. (2018). Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics. Journal of the Intensive Care Society, 19(4), 299-304. https://doi.org/10.1177/1751143718758975

Background Sepsis represents a significant public health burden, costing the NHS £2.5 billion annually, with 35% mortality in 2006. The aim of this exploratory study was to investigate risk factors predictive of 30-day mortality amongst patients w... Read More about Predicting 30-day mortality in patients with sepsis: an exploratory analysis of process of care and patient characteristics.

Barriers to voluntary participation in sport for children: a systematic review (2018)
Journal Article
Somerset, S., & Hoare, D. J. (2018). Barriers to voluntary participation in sport for children: a systematic review. BMC Pediatrics, 18(1), Article 47. https://doi.org/10.1186/s12887-018-1014-1

Background Numerous studies have detailed the physical health benefits of children’s participation in sport and a growing body of research also highlights the benefits for mental health. Children who participate in sport have also been shown to be a... Read More about Barriers to voluntary participation in sport for children: a systematic review.

Hyperacusis: major research questions (2018)
Journal Article
Baguley, D. M., & Hoare, D. J. (2018). Hyperacusis: major research questions. HNO, 66(5), 358-363. https://doi.org/10.1007/s00106-017-0464-3

Background: Hyperacusis is a troublesome symptom that can have a marked negative impact on quality of life. Objectives: To identify major research questions in hyperacusis. Materials and methods: Review of gaps in knowledge regarding hyperacusis, a... Read More about Hyperacusis: major research questions.

Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’ (2018)
Journal Article
Scutt, P., Appleton, J. P., Dixon, M., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., …Bath, P. M. (2018). Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’. European Stroke Journal, 3(2), 193-196. https://doi.org/10.1177/2396987318756696

Rationale: Glyceryl trinitrate, a nitric oxide donor, is a candidate treatment for acute stroke; it lowers blood pressure, does not alter cerebral blood flow or platelet function and is neuroprotective in experimental stroke. The ongoing rapid interv... Read More about Statistical analysis plan for the ‘Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)’.

Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial (2018)
Journal Article
Dineen, R. A., Pszczolkowski, S., Flaherty, K., Law, Z. K., Morgan, P. S., Roberts, I., …Sprigg, N. (in press). Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial. BMJ Open, 8(2), Article e019930. https://doi.org/10.1136/bmjopen-2017-019930

Objectives: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in patients with spontaneous intracerebral haemorrhage (SICH) leads to increased prevalence of diffusion-weighted MRI defined hyperintense ischaemic lesions... Read More about Does tranexamic acid lead to changes in MRI-measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? An MRI sub-study nested within the double-blind randomised controlled TICH-2 trial.