Outputs (120)

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial (2017)
Journal Article
Flaherty, K., Bath, P. M., Dineen, R., Law, Z., Scutt, P., Pocock, S., & Sprigg, N. (in press). Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial. Trials, 18(1), Article 607. https://doi.org/10.1186/s13063-017-2341-5

Rationale

Aside from blood pressure lowering, treatment options for intracerebral haemorrhage remain limited and a proportion of patients will undergo early haematoma expansion with resultant significant morbidity and mortality. Tranexamic acid (T... Read More about Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial.

Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial (2017)
Journal Article
Bath, P. M., Christensen, L. M., Woodhouse, L. J., Bentsen, L., Appleton, J. P., Krarup Hansen, C., Beridze, M., Thomsen, T. T., Christensen, H., Kruuse, C., Dineen, R. A., Jensen, H. H., Duley, L., Hansen, S. S., England, T. J., Petrovic, V., Flaherty, K., Beridze, N., Havard, D., Kakabadze, N., …Farren, P. (2018). Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391(10123), 850-859. https://doi.org/10.1016/S0140-6736%2817%2932849-0

Background: Intensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients with acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive antiplat... Read More about Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial.

Nerve terminals at the human corneoscleral limbus (2017)
Journal Article

Aims: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus.

Methods: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age,... Read More about Nerve terminals at the human corneoscleral limbus.

Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers (2017)
Journal Article
Pronk, M., Deeg, D. J., Versfeld, N. J., Heymans, M., Naylor, G., & Kramer, S. E. (in press). Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers. Trends in Hearing, 21, https://doi.org/10.1177/2331216517744915

This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing probl... Read More about Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers.

Measuring Cerebral and Cerebellar Glutathione in Children Using 1H MEGA-PRESS MRS (2017)
Journal Article
Raschke, F., Noeske, R., Dineen, R., & Auer, D. (2018). Measuring Cerebral and Cerebellar Glutathione in Children Using 1H MEGA-PRESS MRS. American Journal of Neuroradiology, 39(2), 375-379. https://doi.org/10.3174/ajnr.a5457

A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth (2017)
Journal Article
Roque, T., Risser, L., Kersemans, V., Smart, S., Allen, D., Kinchesh, P., …Chappell, M. A. (2018). A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth. IEEE Transactions on Medical Imaging, 37(3), 724-732. https://doi.org/10.1109/tmi.2017.2779811

Predicting tumor growth and its response to therapy remains a major challenge in cancer research and strongly relies on tumor growth models. In this paper, we introduce, calibrate, and verify a novel image-driven reaction-diffusion model of avascular... Read More about A DCE-MRI Driven 3-D Reaction-Diffusion Model of Solid Tumor Growth.

Quality of questionnaires for the assessment of otitis media with effusion in children (2017)
Journal Article
Wei Chern Gan, R., Daniel, M., Ridley, M., & Barry, J. G. (in press). Quality of questionnaires for the assessment of otitis media with effusion in children. Clinical Otolaryngology, 43(2), https://doi.org/10.1111/coa.13026

Objectives
Audiometric tests provide information about hearing in otitis media with effusion (OME). Questionnaires can supplement this information by supporting clinical history‐taking as well as potentially providing a standardized and comprehensiv... Read More about Quality of questionnaires for the assessment of otitis media with effusion in children.

TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2 (2017)
Presentation / Conference Contribution
Sprigg, N., Bath, P. M., Appleton, J., Law, Z., Flaherty, K., Scutt, P., …Ali, A. (2017). TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2.

Rationale: To assess in a pragmatic phase III prospective double blind randomised placebo-controlled trial whether tranexamic acid is safe and reduces death or dependency after spontaneous intracerebral haemorrhage (SICH). The results will determine... Read More about TICH-2 Trial – Tranexamic Acid for Intracerebral Haemorrhage 2.

Survival of corneal nerve/sheath structures in organ-cultured donor corneas (2017)
Journal Article

Purpose
To study the morphology of human corneal nerves in eye bank organ‐cultured corneas and in corneal grafts post‐transplantation.

Methods
Thirty‐seven organ‐cultured corneas were divided into: Group‐A, anterior 300–400 μm of 20 corneas used... Read More about Survival of corneal nerve/sheath structures in organ-cultured donor corneas.

Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (2017)
Journal Article
Winkel, P., Bath, P. M., Gluud, C., Lindschou, J., van der Worp, H. B., Macleod, M. R., …Schwab, S. (in press). Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke. Trials, 18(1), https://doi.org/10.1186/s13063-017-2302-z

Background: Cooling may reduce infarct size and improve neurological outcomes in patients with ischaemic stroke. In phase II trials, cooling awake patients with ischaemic stroke has been shown to be feasible and safe, but the effects in functional ou... Read More about Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.