Outputs (9)

ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies (2019)
Preprint / Working Paper
Mutsaerts, H., Petr, J., Groot, P., Vandemaele, P., Ingala, S., Robertson, A. D., …Barkhof, F. ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies

Arterial spin labeling (ASL) has undergone significant development since its inception, with a focus on improving standardization and reproducibility of its acquisition and quantification. In a community-wide effort towards robust and reproducible cl... Read More about ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies.

Toblerone: Surface-Based Partial Volume Estimation (2019)
Journal Article
Kirk, T. F., Coalson, T. S., Craig, M. S., & Chappell, M. A. (2020). Toblerone: Surface-Based Partial Volume Estimation. IEEE Transactions on Medical Imaging, 39(5), 1501-1510. https://doi.org/10.1109/tmi.2019.2951080

Partial volume effects (PVE) present a source of confound for the analysis of functional imaging data. Correction for PVE requires estimates of the partial volumes (PVs) present in an image. These estimates are conventionally obtained via volumetric... Read More about Toblerone: Surface-Based Partial Volume Estimation.

Calibration of arterial spin labeling data—potential pitfalls in post‐processing (2019)
Journal Article
Pinto, J., Chappell, M. A., Okell, T. W., Mezue, M., Segerdahl, A. R., Tracey, I., …Figueiredo, P. (2020). Calibration of arterial spin labeling data—potential pitfalls in post‐processing. Magnetic Resonance in Medicine, 83(4), 1222-1234. https://doi.org/10.1002/mrm.28000

Purpose
To assess the impact of the different post‐processing options in the calibration of arterial spin labeling (ASL) data on perfusion quantification and its reproducibility.

Theory and Methods
Absolute quantification of perfusion measuremen... Read More about Calibration of arterial spin labeling data—potential pitfalls in post‐processing.

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI (2019)
Journal Article
Zhao, M. Y., Václavů, L., Petersen, E. T., Biemond, B. J., Sokolska, M. J., Suzuki, Y., …Chappell, M. A. (2020). Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI. Magnetic Resonance in Medicine, 83(2), 731-748. https://doi.org/10.1002/mrm.27956

Purpose
To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo‐QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post... Read More about Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI.

Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling (2019)
Journal Article
Msayib, Y., Craig, M., Simard, M. A., Larkin, J. R., Shin, D. D., Liu, T. T., …Chappell, M. A. (2020). Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling. Magnetic Resonance in Medicine, 83(3), 815-829. https://doi.org/10.1002/mrm.27965

Purpose
Multi‐phase PCASL has been proposed as a means to achieve accurate perfusion quantification that is robust to imperfect shim in the labeling plane. However, there exists a bias in the estimation process that is a function of noise in the dat... Read More about Robust estimation of quantitative perfusion from multi‐phase pseudo‐continuous arterial spin labeling.

ICA-based denoising for ASL perfusion imaging (2019)
Journal Article
Carone, D., Harston, G., Garrard, J., De Angeli, F., Griffanti, L., Okell, T., …Kennedy, J. (2019). ICA-based denoising for ASL perfusion imaging. NeuroImage, 200, 363-372. https://doi.org/10.1016/j.neuroimage.2019.07.002

Arterial Spin Labelling (ASL) imaging derives a perfusion image by tracing the accumulation of magnetically labeled blood water in the brain. As the image generated has an intrinsically low signal to noise ratio (SNR), multiple measurements are routi... Read More about ICA-based denoising for ASL perfusion imaging.

Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages (2019)
Journal Article
Suri, S., Topiwala, A., Chappell, M. A., Okell, T. W., Zsoldos, E., Singh-Manoux, A., …Ebmeier, K. P. (2019). Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages. JAMA Network Open, 2(6), Article e195776. https://doi.org/10.1001/jamanetworkopen.2019.5776

© 2019 AMA. All rights reserved. Importance: Poor cardiovascular health is an established risk factor for dementia, but little is known about its association with brain physiology in older adults. Objective: To examine the association of cardiovascul... Read More about Association of Midlife Cardiovascular Risk Profiles with Cerebral Perfusion at Older Ages.

High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging (2019)
Journal Article
van der Plas, M. C., Teeuwisse, W. M., Schmid, S., Chappell, M., & van Osch, M. J. (2019). High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging. Magnetic Resonance in Medicine, 81(6), 3734-3744. https://doi.org/10.1002/mrm.27692

Purpose
The goal of this study was to achieve high temporal resolution, multi‐time point pseudo‐continuous arterial spin labeling (pCASL) MRI in a time‐efficient manner, while maintaining whole‐brain coverage.

Methods
A Hadamard 8‐matrix was use... Read More about High temporal resolution arterial spin labeling MRI with whole-brain coverage by combining time-encoding with Look-Locker and simultaneous multi-slice imaging.

Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging (2019)
Journal Article
Ray, K. J., Simard, M. A., Larkin, J. R., Coates, J., Kinchesh, P., Smart, S. C., …Sibson, N. R. (2019). Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging. Cancer Research, 79(7), 1343-1352. https://doi.org/10.1158/0008-5472.can-18-2168

Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet multiple facto... Read More about Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging.