Outputs (42)

The current provision of community-based teaching in UK medical schools: an online survey and systematic review (2014)
Journal Article
Lee, S. W., Clement, N., Tang, N., & Atiomo, W. (2014). The current provision of community-based teaching in UK medical schools: an online survey and systematic review. BMJ Open, 4, Article e005696. https://doi.org/10.1136/bmjopen-2014-005696

Objective: To evaluate the current provision and outcome of community-based education (CBE) in UK medical schools.
Design and data sources: An online survey of UK medical school websites and course prospectuses and a systematic review of articles f... Read More about The current provision of community-based teaching in UK medical schools: an online survey and systematic review.

Prophylactic anti-staphylococcal antibiotics for cystic fibrosis (2014)
Journal Article
Smyth, A. R., & Walters, S. (2014). Prophylactic anti-staphylococcal antibiotics for cystic fibrosis. Cochrane Library, Article CD001912. https://doi.org/10.1002/14651858.CD001912.pub3

Background
Staphylococcus aureus causes pulmonary infection in young children with cystic fibrosis. Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term use might le... Read More about Prophylactic anti-staphylococcal antibiotics for cystic fibrosis.

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2014)
Journal Article
Langton Hewer, S. C., & Smyth, A. R. (2014). Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Library, https://doi.org/10.1002/14651858.CD004197.pub4

Background: Respiratory tract infection with Pseudomonas aeruginosa occurs inmost people with cystic fibrosis. Once chronic infection is established, Pseudomonas aeruginosa is virtually impossible to eradicate and is associated with increased mortali... Read More about Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis.

Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia (2014)
Journal Article
Mistry, H. D., Gill, C., Kurlak, L., Seed, P. T., Hestketh, J., Meplan, C., Schomburg, L., Chappell, L. C., Morgan, L., & Poston, L. (2015). Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia. Free Radical Biology and Medicine, 78, https://doi.org/10.1016/j.freeradbiomed.2014.10.580

Aims: Pre-eclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Deficiencies of specific micronutrient antioxidant activities associated with copper, selenium, zinc... Read More about Association between maternal micronutrient status, oxidative stress and common genetic variants in antioxidant enzymes at 15 weeks’ gestation in nulliparous women who subsequently develop pre-eclampsia.

Maternal endocrine adaptation throughout pregnancy to nutrient manipulation: Consequences for sexually dimorphic programming of thyroid hormones and development of their progeny (2014)
Journal Article
Micke, G., Sullivan, T., Kennaway, D., Hernandez-Medrano, J., & Perry, V. (2015). Maternal endocrine adaptation throughout pregnancy to nutrient manipulation: Consequences for sexually dimorphic programming of thyroid hormones and development of their progeny. Theriogenology, 83(4), 604-615. https://doi.org/10.1016/j.theriogenology.2014.10.022

Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration (2014)
Journal Article
Khan, G. H., Galazis, N., Docheva, N., Layfield, R., & Atiomo, W. (2014). Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration. Human Reproduction, 30(1), https://doi.org/10.1093/humrep/deu268

Study question: Do any proteomic biomarkers previously identified for pre-eclampsia (PE) overlap with those identified in women with polycystic ovary syndrome (PCOS).
Summary answer: Five previously identified proteomic biomarkers were found to be c... Read More about Overlap of proteomics biomarkers between women with pre-eclampsia and PCOS: a systematic review and biomarker database integration.

Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland (2014)
Journal Article
Duong, T., Judd, A., Collins, I. J., Doerholt, K., Lyall, H., Foster, C., Butler, K., Tookey, P., Shingadia, D., Menson, E., Dunn, D. T., Gibb, D. M., & Smyth, A. R. (2014). Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland. AIDS, 28(16), https://doi.org/10.1097/QAD.0000000000000438

Objective: To assess factors at the start of antiretroviral therapy (ART) associated with long-term virological response in children.
Design: Multicentre national cohort.
Methods: Factors associated with viral load below 400 copies/ml by 12 months... Read More about Long-term virological outcome in children on antiretroviral therapy in the UK and Ireland.

Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol (2014)
Journal Article
Jayaprakasan, K., Narkwichean, A., Maalouf, W. E., & Campbell, B. K. (2014). Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol. BMJ Open, 4(10), Article e005767. https://doi.org/10.1136/bmjopen-2014-005767

Introduction: Dehydroepiandrosterone (DHEA) has been proposed to improve pregnancy rates in women with diminished ovarian reserve undergoing in vitro fertilisation (IVF) treatment. However, evidence regarding its efficacy is supported by a limited n... Read More about Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (DITTO): a proof of principle randomised controlled trial protocol.

Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma (2014)
Journal Article
Smith, S. J., Rahman, C. V., Ritchie, A. A., Gould, T. W., Ward, J. H., Shakesheff, K. M., …Clarke, P. A. (2014). Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma. Annals of The Royal College of Surgeons of England, 96(7), 495-501. https://doi.org/10.1308/003588414X13946184903568

Introduction: The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) remains less than 18 months despite radical surgery, radiotherapy and systemic chemotherapy. Surgical implantation of chemotherapy eluting wafers into th... Read More about Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma.

Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP trial (2014)
Journal Article
Cooper, S., Taggar, J., Lewis, S., Marlow, N., Dickinson, A., Whitemore, R., & Coleman, T. (2014). Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP trial. Lancet Respiratory Medicine, 2(9), https://doi.org/10.1016/S2213-2600%2814%2970157-2

BACKGROUND:
The SNAP (Smoking and Nicotine in Pregnancy) trial compared nicotine replacement therapy (NRT) patches with placebo in pregnant smokers; although NRT doubled cessation rates in the first 4 weeks, by delivery no differences in maternal sm... Read More about Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP trial.