Outputs (458)

Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis (2021)
Journal Article
Marsh, R., Gavillet, H., Hanson, L., Ng, C., Mitchell-Whyte, M., Major, G., …van der Gast, C. (2022). Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis. Journal of Cystic Fibrosis, https://doi.org/10.1016/j.jcf.2021.11.014

Background: Most people with cystic fibrosis (pwCF) suffer from gastrointestinal symptoms and are at risk of gut complications. Gut microbiota dysbiosis is apparent within the CF population across all age groups, with evidence linking dysbiosis to in... Read More about Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis.

COVID-19 and pregnancy: A comparison of case reports, case series and registry studies (2021)
Journal Article
Young, E. M., Green, O., Stewart, J., King, Y., O'Donoghue, K., Walker, K. F., & Thornton, J. G. (2022). COVID-19 and pregnancy: A comparison of case reports, case series and registry studies. European Journal of Obstetrics and Gynecology and Reproductive Biology, 268, 135-142. https://doi.org/10.1016/j.ejogrb.2021.12.002

Background: Selection, outcome and publication biases are well described in case reports and case series but may be less of a problem early in the appearance of a new disease when all cases might appear to be worth publishing. Objective: To use a pro... Read More about COVID-19 and pregnancy: A comparison of case reports, case series and registry studies.

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma (2021)
Journal Article
Dury, R. J., Lourdusamy, A., Macarthur, D. C., Peet, A. C., Auer, D. P., Grundy, R. G., & Dineen, R. A. (2022). Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma. Journal of Magnetic Resonance Imaging, 56(1), 147-157. https://doi.org/10.1002/jmri.28007

Background: Medulloblastoma, ependymoma, and pilocytic astrocytoma are common pediatric posterior fossa tumors. These tumors show overlapping characteristics on conventional MRI scans, making diagnosis difficult. Purpose: To investigate whether appar... Read More about Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.

Investigating histidinylated highly branched poly(lysine) for siRNA delivery (2021)
Journal Article
Alazzo, A., Gumus, N., Gurnani, P., Stolnik, S., Rahman, R., Spriggs, K., & Alexander, C. (2022). Investigating histidinylated highly branched poly(lysine) for siRNA delivery. Journal of Materials Chemistry B, 10(2), 236-246. https://doi.org/10.1039/d1tb01793d

The temporary silencing of disease-associated genes utilising short interfering RNA (siRNA) is a potent and selective route for addressing a wide range of life limiting disorders. However, the few clinically approved siRNA therapies rely on lipid bas... Read More about Investigating histidinylated highly branched poly(lysine) for siRNA delivery.

Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT (2021)
Journal Article
Langton Hewer, S. C., Smyth, A. R., Brown, M., Jones, A. P., Hickey, H., Kenna, D., …Williamson, P. R. (2021). Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT. Health Technology Assessment, 25(65), 1-158. https://doi.org/10.3310/hta25650

Background People with cystic fibrosis are susceptible to pulmonary infection with Pseudomonas aeruginosa. This may become chronic and lead to increased mortality and morbidity. If treatment is commenced promptly, infection may be eradicated through... Read More about Intravenous or oral antibiotic treatment in adults and children with cystic fibrosis and Pseudomonas aeruginosa infection: the TORPEDO-CF RCT.

Case of successfully delivered dicavitary twins in uterus didelphus (2021)
Journal Article
Barnes, E., Walker, K., Sayed, H. M., & Green, A. (2021). Case of successfully delivered dicavitary twins in uterus didelphus. BMJ Case Reports, 14(11), e245139. https://doi.org/10.1136/bcr-2021-245139

Uterus didelphus is a congenital abnormality arising from failure of fusion of Mullerian ducts, creating two separate uterine horns, two cervices and, in some cases, a vagina divided by a longitudinal septum. In this case, a 26-year-old woman with pr... Read More about Case of successfully delivered dicavitary twins in uterus didelphus.

Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic (2021)
Journal Article
Williams, G., McLean, R., Liu, J. F., Ritzmann, T. A., Dandapani, M., Shanmugavadivel, D., …Walker, D. (2021). Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic. BMJ Paediatrics Open, 5(1), Article e001078. https://doi.org/10.1136/bmjpo-2021-001078

Background The COVID-19 pandemic led to changes in patterns of presentation to emergency departments. Child health professionals were concerned that this could contribute to the delayed diagnosis of life-threatening conditions, including childhood ca... Read More about Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic.

Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells (2021)
Journal Article
Robinson, A. J., Jain, A., Rahman, R., Abayzeed, S., Hague, R. J., & Rawson, F. J. (2021). Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells. ACS Omega, 6(44), 29495-29505. https://doi.org/10.1021/acsomega.1c03547

Merging of electronics with biology, defined as bioelectronics, at the nanoscale holds considerable promise for sensing and modulating cellular behavior. Advancing our understanding of nanobioelectronics will facilitate development and enable applica... Read More about Impedimetric Characterization of Bipolar Nanoelectrodes with Cancer Cells.

Anti-reflux medication use in preterm infants (2021)
Journal Article
Binti Abdul Hamid, H., Szatkowski, L., Budge, H., & Ojha, S. (2022). Anti-reflux medication use in preterm infants. Pediatric Research, 92, 520-525. https://doi.org/10.1038/s41390-021-01821-y

Background: Current recommendations do not support the use of anti-reflux medications to treat gastro-oesophageal reflux disease (GORD) among preterm infants. Objective: To describe the prevalence of GORD and the use of anti-reflux medications amongs... Read More about Anti-reflux medication use in preterm infants.

Paternal periconception metabolic health and offspring programming (2021)
Journal Article
Eid, N., Morgan, H. L., & Watkins, A. J. (2021). Paternal periconception metabolic health and offspring programming. Proceedings of the Nutrition Society, https://doi.org/10.1017/S0029665121003736

The association between maternal metabolic status at the time of conception and subsequent embryogenesis and offspring development has been studied in detail. However, less attention has been given to the significance of paternal nutrition and metabo... Read More about Paternal periconception metabolic health and offspring programming.